Fig. 1

Experimental setting. A. Representative images of whole livers from 20-week-old L-dKO (tumors are indicated with arrowheads) and control mice. B. Three independent tumor samples were taken from each of four 20-week-old L-dKO mice. For each mouse, one muscle sample was used as the matched healthy tissue. This setting was used for exome sequencing. Each of the three tumor nodules was compared against the matched muscle tissue sample. C. Three independent tumor samples were taken from each of four 20-week-old L-dKO mice. Liver tissues from six cre-negative age- and sex- matched littermates were used as a control. This setting was used for mRNA sequencing, miRNA sequencing, proteome and phosphoproteome quantification