Table 3 Pathway enrichment results by using Metacore tool

1

Cell cycle_G1-S Growth factor regulation

195

3.776E-15

2.760E-13

21

AKT3, GRB2, NF-kB, VEGF-A, EGFR, STAT3, c-Myc, Cyclin D, GSK3 alpha/beta, N-Ras, AKT(PKB), NF-kB p50/p50, AKT2, c-Raf-1, GSK3 beta, IRS-1, IGF-1 receptor, AKT1, Cyclin D1, NF-kB1 (p50), SMAD4

2

Cell cycle_G1-S Interleukin regulation

128

3.972E-15

2.760E-13

18

AKT3, GRB2, NF-kB, STAT3, c-Myc, Cyclin D, GSK3 alpha/beta, N-Ras, AKT(PKB), NF-kB p50/p50, AKT2, c-Raf-1, GSK3 beta, Elk-1, IRS-1, AKT1, Cyclin D1, NF-kB1 (p50)

3

Development_Hemopoiesis, Erythropoietin pathway

136

1.868E-13

8.656E-12

17

GRB2, SHIP, NF-kB, STAT3, c-Kit, c-Myc, Cyclin D, N-Ras, AKT(PKB), Bim, NF-kB p50/p50, c-Raf-1, K-RAS, FOXO3A, Elk-1, AKT1, Cyclin D1

4

Signal transduction_NOTCH signaling

235

1.677E-11

5.215E-10

19

GRB2, NF-kB, VEGF-A, NF-kB1 (p105), EGFR, STAT3, c-Myc, AKT(PKB), AKT2, c-Raf-1, Skp2/TrCP/FBXW, GSK3 beta, Cyclin D1, PTEN, mTOR, NF-kB1 (p50), SMAD4, FBXW7, HIF1A

5

Signal Transduction_TGF-beta, GDF and Activin signaling

154

1.876E-11

5.215E-10

16

SIP1 (ZFHX1B), GRB2, NF-kB, EGFR, RUNX2, c-Kit, c-Myc, AKT(PKB), c-Raf-1, IRS-1, IGF-1 receptor, Cyclin D1, mTOR, SMAD4, HIF1A, CREB1

6

Signal transduction_ERBB-family signaling

75

4.616E-11

1.069E-09

12

GRB2, NF-kB, EGFR, STAT3, c-Myc, N-Ras, AKT(PKB), c-Raf-1, K-RAS, Elk-1, IRS-1, PTEN

7

Development_EMT_Regulation of epithelial-to-mesenchymal transition

224

6.898E-11

1.254E-09

18

SIP1 (ZFHX1B), GRB2, EGFR, TCF8, STAT3, EGR1, ROCK1, AKT(PKB), c-Raf-1, GSK3 beta, Elk-1, TNF-alpha, CTGF, PTEN, mTOR, SMAD4, HIF1A, CREB1

8

Inflammation_IL-6 signaling

119

7.216E-11

1.254E-09

14

AKT3, GRB2, NF-kB, STAT3, c-Myc, AKT(PKB), NF-kB p50/p50, AKT2, c-Raf-1, 14-3-3 zeta/delta, Elk-1, AKT1, NF-kB1 (p50), 14-3-3

9

Signal transduction_Leptin signaling

107

2.434E-10

3.760E-09

13

GRB2, NF-kB, VEGF-A, STAT3, EGR1, GSK3 alpha/beta, AKT(PKB), AKT2, c-Raf-1, IRS-1, AMPK alpha subunit, HIF1A, CREB1

10

Cardiac development_Role of NADPH oxidase and ROS

134

3.626E-10

4.742E-09

14

GRB2, HDAC5, MEF2C, NF-kB, GSK3 alpha/beta, AKT(PKB), TBX3, c-Raf-1, GSK3 beta, SMAD5, Hamartin, PTEN, SMAD4, HIF1A

11

Reproduction_FSH-beta signaling pathway

160

3.752E-10

4.742E-09

15

NF-kB, VEGF-A, EGFR, EGR1, c-Myc, Cyclin D, AKT(PKB), c-Raf-1, IRS-1, IGF-1 receptor, CTGF, mTOR, SMAD4, HIF1A, CREB1

12

Signal transduction_Androgen receptor signaling cross-talk

72

5.284E-10

6.120E-09

11

GRB2, NF-kB, EGFR, STAT3, AKT(PKB), c-Raf-1, FOXO3A, GSK3 beta, IGF-1 receptor, mTOR, CREB1

13

Inflammation_Amphoterin signaling

118

8.432E-10

9.015E-09

13

ROCK, AKT3, NF-kB, NF-kB1 (p105), ROCK1, AKT(PKB), NF-kB p50/p50, AKT2, c-Raf-1, Elk-1, AKT1, TNF-alpha, NF-kB1 (p50)

14

Signal transduction_ESR1-membrane pathway

91

6.908E-09

6.859E-08

11

GRB2, EGFR, GSK3 alpha/beta, AKT(PKB), c-Raf-1, GSK3 beta, Elk-1, IRS-1, IGF-1 receptor, Cyclin D1, CREB1

15

Inflammation_TREM1 signaling

145

1.087E-08

1.007E-07

13

AKT3, GRB2, MEF2C, NF-kB, EGR1, AKT(PKB), AKT2, c-Raf-1, 14-3-3 zeta/delta, Elk-1, AKT1, TNF-alpha, 14-3-3

16

Translation_Regulation of initiation

127

2.325E-08

1.968E-07

12

AKT3, GRB2, EGFR, GSK3 alpha/beta, AKT(PKB), AKT2, c-Raf-1, GSK3 beta, IRS-1, Hamartin, AKT1, mTOR

17

Signal transduction_ESR1-nuclear pathway

216

2.407E-08

1.968E-07

15

GRB2, VEGF-A, NF-kB1 (p105), EGFR, c-Myc, AKT(PKB), AKT2, c-Raf-1, GSK3 beta, IRS-1, HDAC4, IGF-1 receptor, Cyclin D1, NF-kB1 (p50), SMAD4

18

Development_Hedgehog signaling

253

2.929E-08

2.262E-07

16

GRB2, VEGF-A, TCF8, EGR1, c-Myc, Sirtuin1, ROCK1, c-Raf-1, Skp2/TrCP/FBXW, GSK3 beta, SMAD5, AKT1, Cyclin D1, SMAD4, FBXW7, CREB1

19

Development_Regulation of angiogenesis

222

3.480E-08

2.546E-07

15

GRB2, NF-kB, VEGF-A, EGFR, TCF8, STAT3, c-Myc, AKT(PKB), c-Raf-1, CTGF, SMAD4, HIF1A, IGFBP7/8, CREB1, VEGFR-1

20

Immune response_BCR pathway

137

5.467E-08

3.800E-07

12

GRB2, SHIP, NF-kB, EGR1, GSK3 alpha/beta, AKT(PKB), NF-kB p50/p50, c-Raf-1, Elk-1, PTEN, mTOR, NF-kB1 (p50)

21

Signal transduction_Nitric oxide signaling

88

6.433E-08

4.258E-07

10

NF-kB, VEGF-A, AKT(PKB), NF-kB p50/p50, c-Raf-1, Elk-1, IRS-1, CaMK II alpha, TNF-alpha, CREB1

22

Inflammation_IL-13 signaling pathway

91

8.902E-08

5.624E-07

10

GRB2, STAT3, ARG1, c-Myc, AKT(PKB), c-Raf-1, Elk-1, IRS-1, NF-kB1 (p50), CREB1

23

Immune response_TCR signaling

174

9.726E-08

5.669E-07

13

ROCK, GRB2, NF-kB, NF-kB1 (p105), ROCK1, AKT(PKB), Bim, NF-kB p50/p50, c-Raf-1, Elk-1, AKT1, TNF-alpha, NF-kB1 (p50)

24

Cell cycle_G2-M

206

9.789E-08

5.669E-07

14

AKT3, GRB2, EGFR, c-Myc, AKT(PKB), AKT2, DNMT1, c-Raf-1, Skp2/TrCP/FBXW, 14-3-3 zeta/delta, HDAC4, IGF-1 receptor, AKT1, 14-3-3

25

Cardiac development_FGF_ErbB signaling

124

1.804E-07

1.003E-06

11

GRB2, MEF2C, EGFR, FOG2, Neurofibromin, AKT(PKB), TBX3, c-Raf-1, GSK3 beta, Versican, Hamartin

26

Inflammation_IL-10 anti-inflammatory response

87

6.923E-07

3.701E-06

9

NF-kB, STAT3, c-Myc, Cyclin D, AKT(PKB), NF-kB p50/p50, Cyclin D1, TNF-alpha, NF-kB1 (p50)

27

Inflammation_IL-4 signaling

115

8.212E-07

4.228E-06

10

GRB2, SHIP, NF-kB, AKT(PKB), Bim, c-Raf-1, GSK3 beta, Elk-1, IRS-1, PTEN

28

Signal Transduction_BMP and GDF signaling

91

1.018E-06

5.054E-06

9

RUNX2, c-Myc, AKT(PKB), YY1, AKT2, SMAD5, AKT1, SMAD4, CREB1

29

Apoptosis_Anti-Apoptosis mediated by external signals via PI3K/AKT

233

2.791E-06

1.338E-05

13

GRB2, NF-kB, VEGF-A, EGFR, AKT(PKB), Bim, NF-kB p50/p50, FOXO3A, IRS-1, IGF-1 receptor, TNF-alpha, NF-kB1 (p50), VEGFR-1

30

Inflammation_IL-2 signaling

104

3.152E-06

1.461E-05

9

GRB2, NF-kB, STAT3, AKT(PKB), NF-kB p50/p50, c-Raf-1, Elk-1, PTEN, NF-kB1 (p50)

31

Proliferation_Positive regulation cell proliferation

221

9.263E-06

4.154E-05

12

GRB2, VEGF-A, EGFR, STAT3, c-Kit, c-Myc, AKT(PKB), c-Raf-1, GSK3 beta, IGF-1 receptor, Cyclin D1, VEGFR-1

32

Cardiac development_Wnt_beta-catenin, Notch, VEGF, IP3 and integrin signaling

151

9.785E-06

4.250E-05

10

MEF2C, VEGF-A, GSK3 alpha/beta, TBX3, c-Raf-1, GSK3 beta, Versican, MEF2, PTEN, VEGFR-1

33

Development_Blood vessel morphogenesis

228

1.272E-05

5.358E-05

12

GRB2, NF-kB, VEGF-A, EGFR, STAT3, c-Myc, AKT(PKB), c-Raf-1, CTGF, HIF1A, IGFBP7/8, VEGFR-1

34

Reproduction_Feeding and Neurohormone signaling

210

3.159E-05

1.292E-04

11

NF-kB, STAT3, c-Kit, c-Myc, AKT(PKB), c-Raf-1, Elk-1, TNF-alpha, mTOR, HIF1A, CREB1

35

Proliferation_Negative regulation of cell proliferation

184

5.446E-05

2.163E-04

10

GRB2, KLF4, EGR1, Neurofibromin, c-Myc, Mxi1, c-Raf-1, Elk-1, IGF-1 receptor, Cyclin D1

36

Immune response_IL-5 signalling

38

7.474E-05

2.886E-04

5

GRB2, STAT3, c-Myc, AKT(PKB), c-Raf-1

37

Muscle contraction_Nitric oxide signaling in the cardiovascular system

124

9.686E-05

3.639E-04

8

MEF2C, VEGF-A, Sirtuin1, AKT(PKB), AMPK alpha 1 subunit, Elk-1, HIF1A, CREB1

38

Apoptosis_Anti-Apoptosis mediated by external signals by Estrogen

95

1.178E-04

4.309E-04

7

GRB2, c-Myc, AKT(PKB), c-Raf-1, Elk-1, NF-kB1 (p50), CREB1

39

Development_ERK5 in cell proliferation and neuronal survival

24

1.597E-04

5.691E-04

4

MEF2C, c-Myc, c-Raf-1, CREB1

40

Proliferation_Lymphocyte proliferation

210

1.643E-04

5.711E-04

10

AKT3, GRB2, NF-kB, STAT3, AKT(PKB), AKT2, c-Raf-1, AKT1, TNF-alpha, mTOR

41

Cell adhesion_Integrin-mediated cell-matrix adhesion

214

1.918E-04

6.280E-04

10

ROCK, GRB2, Caveolin-2, c-Myc, ROCK1, AKT(PKB), c-Raf-1, GSK3 beta, Hamartin, Cyclin D1

42

Reproduction_Progesterone signaling

214

1.918E-04

6.280E-04

10

GRB2, VEGF-A, EGFR, STAT3, c-Myc, c-Raf-1, GSK3 beta, IGF-1 receptor, AKT1, CREB1

43

Inflammation_IgE signaling

137

1.943E-04

6.280E-04

8

GRB2, NF-kB, AKT(PKB), NF-kB p50/p50, c-Raf-1, Elk-1, TNF-alpha, NF-kB1 (p50)

44

Inflammation_Neutrophil activation

215

1.992E-04

6.294E-04

10

ROCK, GRB2, NF-kB, STAT3, ROCK1, AKT(PKB), NF-kB p50/p50, c-Raf-1, TNF-alpha, NF-kB1 (p50)

45

Inflammation_MIF signaling

140

2.256E-04

6.967E-04

8

GRB2, NF-kB, Cyclin D, NF-kB p50/p50, Cyclin D1, TNF-alpha, NF-kB1 (p50), CREB1

46

Apoptosis_Anti-Apoptosis mediated by external signals via MAPK and JAK/STAT

179

2.375E-04

7.176E-04

9

GRB2, STAT3, EGR1, c-Myc, Bim, c-Raf-1, Elk-1, TNF-alpha, CREB1

47

Inflammation_Protein C signaling

108

2.628E-04

7.606E-04

7

ROCK, NF-kB, ROCK1, AKT(PKB), NF-kB p50/p50, TNF-alpha, NF-kB1 (p50)

48

Signal transduction_ESR2 pathway

77

2.727E-04

7.606E-04

6

GRB2, VEGF-A, EGFR, c-Raf-1, AKT1, TNF-alpha

49

Apoptosis_Apoptosis stimulation by external signals

144

2.736E-04

7.606E-04

8

GRB2, SHIP, NF-kB, AKT(PKB), Bim, c-Raf-1, TNF-alpha, SMAD4

50

Development_Skeletal muscle development

144

2.736E-04

7.606E-04

8

HDAC5, MEF2C, VEGF-A, Sirtuin, Histone deacetylase class II, Sirtuin1, HDAC4, MEF2

Info

Date

21/07/2018

Server

portal.genego.com

Version

6.35.69300

Type

Enrichment analysis

Signals

both

Name

Type

Size

74_NetICS_mouse_data_hub_19_Jul_2018_genelist

General

74