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Table 7 Combination rules for differentially expressed genes

From: Multi-omics data integration reveals novel drug targets in hepatocellular carcinoma

Combinations

  

RNA

PROT or PH

Output

Significant/Insignificant

Significant

PROT or PH

Significant/Insignificant

Insignificant

Not taken

Significant

Not Detected

RNA

Insignificant

Not Detected

Not taken

Not Detected

Not Detected

Not taken

  1. The genes at the downstream level are combined as follows: If the protein is significantly changed at the proteome or phosphoproteome levels, it is taken into account in the set of differentially expressed genes/proteins given as input in NetICS. If the protein is detected but not significantly changed at the proteome or phosphoproteome levels, it is not taken into account. If the protein or its phosphosites are not detected at all, then the change at the RNA level is taken into account.
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BMC Genomics

ISSN: 1471-2164

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