Fig. 5

Identification of the two immune subtypes in the THCA cohort. A Heatmap of the two immune subtypes based on ssGSEA algorithm for 28 immune gene sets. B The correlation heatmap demonstrates the relationship between ferroptosis genes expressions and immune cells infiltration. Dots size shows the extent of their relationships and dots colour indicates if they are positive-related (red dots) or negative-related (blue dots). The number on the scale bar indicates the coefficients of correlation between genes expression and cells infiltration. Blank squares mean insignificance (P-value > 0.05). C The abundance of each TME infiltrating cell in THCA modification patterns. The upper and lower ends of the boxes represented interquartile range of values. The lines in the boxes represented median value, and black dots showed outliers. The asterisks represented the statistical P-value (*P < 0.05; **P < 0.01; ***P < 0.001; ****P < 0.0001)