Fig. 7From: Reverse complementary matches simultaneously promote both back-splicing and exon-skipping A proposed model that RCMs promote both back-splicing and exon-skipping at the same time. (1) Canonical splicing to form full-length linear mRNA. (2) RCMs facilitate circRNA formation by bringing splice sites for back-splicing sites together. The y-shaped intermediate is further spliced to form the skipped transcript. (3) RCMs promote exon-skipping by bringing splice sites for exon-skipping together. The lariat intermediate is further back-spliced to form circRNA. RCMs in the y-shaped intermediate and the lariat intermediate may help the second splicing stepsBack to article page