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Fig. 7 | BMC Genomics

Fig. 7

From: Reverse complementary matches simultaneously promote both back-splicing and exon-skipping

Fig. 7

 A proposed model that RCMs promote both back-splicing and exon-skipping at the same time. (1) Canonical splicing to form full-length linear mRNA. (2) RCMs facilitate circRNA formation by bringing splice sites for back-splicing sites together. The y-shaped intermediate is further spliced to form the skipped transcript. (3) RCMs promote exon-skipping by bringing splice sites for exon-skipping together. The lariat intermediate is further back-spliced to form circRNA. RCMs in the y-shaped intermediate and the lariat intermediate may help the second splicing steps

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