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Fig. 5 | BMC Genomics

Fig. 5

From: Inhibition of CUB and sushi multiple domains 1 (CSMD1) expression by miRNA-190a-3p enhances hypertrophic scar-derived fibroblast migration in vitro

Fig. 5

Transcription profiling identified an activation of JAK/STAT signaling pathway in the CSMD1-silenced fibroblasts. (A) Scatter plots of differentially expressed genes. 1001 genes were significantly up-regulated (red) while 966 genes were significantly down-regulated (green). Fold change> 1.5, p < 0.05. (B, C) Both Kyoto Encyclopedia of Genes and Genomes analysis and Gene Set Enrichment analysis revealed that JAK/STAT signaling pathway was the most significantly up-regulated pathway identified upon CSMD1 silencing. (D) qRT-PCR was performed to detect mRNA levels of the three essential genes in the JAK/STAT signaling pathway in fibroblasts treated with Lenti-shRNA-CSMD1 and was compared with its corresponding negative controls. JAK1, STAT5A and PIK3CA were significantly up-regulated in fibroblasts treated with Lenti-shRNA-CSMD1. All experiments were performed in triplicate and the data were shown as mean ± SD. **p < 0.01, ****p < 0.0001

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BMC Genomics

ISSN: 1471-2164

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