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Table 2 Odds ratios (95%CI) of general obesity for different SNPs in different smoke exposure groups

From: Brain-derived neurotrophic factor gene variants and obesity in former smokers

  

Never smokers

 

Former smokers

 

Current smokers

Male

General obesity‡ n(%)

Model A

Model B

Model C

Cases

Model A

Model B

Model C

Cases

Model A

Model B

Model C

Rs6265

 AA

37 (10.4)

1

1

1

21 (7.5)

1

1

1

14 (5.9)

1

1

1

 GA

72 (11.6)

1.13 (0.74–1.72)

1.11 (0.73–1.69)

1.11 (0.73–1.69)

39 (7.5)

1.00 (0.58–1.74)

1.02 (0.59–1.77)

1.01 (0.58–1.76)

27 (6.3)

1.07 (0.55–2.09)

1.08 (0.55–2.09)

1.07 (0.55–2.08)

 GG

15 (5.3)

0.48 (0.26–0.90)

0.48 (0.26–0.89)

0.48 (0.26–0.89)

31 (13.0)

1.85 (1.03–3.31)

1.88 (1.05–3.37)

1.87 (1.04–3.36)

17 (8.2)

1.42 (0.68–2.95)

1.42 (0.68–2.96)

1.39 (0.67–2.91)

P for G

 

0.049

0.043

0.044

 

0.024**

0.03*

0.014**

 

0.348

0.346

0.379

Rs4923457

 TT

34 (11.3)

1

1

1

20 (7.6)

1

1

1

10 (5.0)

1

1

1

 AT

74 (11.4)

1.01 (0.66–1.56)

0.99 (0.64–1.53)

0.99 (0.64–1.53)

37 (7.3)

0.96 (0.54–1.68)

0.97 (0.55–1.70)

0.96 (0.54–1.69)

30 (7.1)

1.44 (0.69–3.01)

1.45 (0.69–3.03)

1.44 (0.69–3.01)

 AA

16 (5.1)

0.42 (0.23–0.78)

0.42 (0.23–0.78)

0.42 (0.23–0.78)

34 (12.6)

1.74 (1.01–3.12)

1.79 (1.00–3.20)

1.79 (1.00–3.20)

18 (7.4)

1.51 (0.68–3.36)

1.52 (0.68–3.37)

1.50 (0.67–3.33)

P for A

 

0.010**

0.019**

0.015**

 

0.012**

0.011**

0.009**

 

0.335

0.333

0.351

Rs11030104

 GG

38 (10.6)

1

1

1

19 (6.9)

1

1

1

15 (6.4)

1

1

1

 AG

71 (11.3)

1.07 (0.70–1.62)

1.05 (0.69–1.59)

1.05 (0.69–1.6)

42 (7.9)

1.15 (0.66–2.02)

1.17 (0.67–2.06)

1.16 (0.66–2.04)

26 (6.2)

0.97 (0.50–1.87)

0.97 (0.50–1.87)

0.96 (0.50–1.85)

 AA

15 (5.4)

0.48 (0.26–0.89)

0.48 (0.26–0.88)

0.48 (0.26–0.89)

30 (12.9)

1.99 (1.09–3.65)

2.04 (1.11–3.73)

2.04 (1.11–3.73)

17 (8.1)

1.29 (0.63–2.65)

1.29 (0.63–2.66)

1.26 (0.61–2.61)

P for A

 

0.043*

0.011**

0.039*

 

0.021**

0.018**

0.018**

 

0.487

0.483

0.530

Rs6484320

 TT

37 (10.9)

1

1

1

21 (7.7)

1

1

1

13 (5.8)

1

1

1

 TA

71 (11.2)

1.03 (0.68–1.57)

1.02 (0.67–1.55)

1.01 (0.66–1.55)

41 (7.9)

1.03 (0.60–1.79)

1.04 (0.60–1.81)

1.04 (0.60–1.80)

29 (6.7)

1.17 (0.60–2.3)

1.17 (0.60–2.31)

1.17 (0.60–2.30)

 AA

16 (5.5)

0.47 (0.26–0.87)

0.47 (0.25–0.86)

0.47 (0.25–0.86)

29 (11.9)

1.63 (0.90–2.93)

1.65 (0.91–2.98)

1.65 (0.91–2.97)

16 (7.5)

1.31 (0.62–2.8)

1.31 (0.62–2.8)

1.29 (0.60–2.76)

P for A

 

0.029*

0.025*

0.025*

 

0.099

0.091

0.092

 

0.483

0.482

0.516

Female

            

Rs6265

 AA

328 (10.8)

1

1

1

7 (12.7)

1

1

1

5 (19.2)

1

1

1

 GA

691 (11.8)

1.11 (0.96–1.27)

1.11 (0.96–1.27)

1.11 (0.96–1.27)

16 (15.8)

1.29 (0.5–3.36)

1.37 (0.52–3.62)

1.36 (0.51–3.64)

7 (12.1)

0.58 (0.16–2.02)

0.39 (0.10–1.51)

0.29 (0.07–1.27)

 GG

327 (12.1)

1.13 (0.96–1.33)

1.13 (0.96–1.33)

1.13 (0.96–1.34)

7 (17.5)

1.46 (0.47–4.54)

1.45 (0.46–4.52)

1.47 (0.46–4.64)

3 (8.8)

0.41 (0.09–1.89)

0.32 (0.06–1.61)

0.26 (0.05–1.43)

P for G

 

0.131

0.131

0.126

 

0.051

0.062

0.053

 

0.142

0.166

0.130

Rs4923457

 TT

312 (11.3)

1

1

1

5 (9.6)

1

1

1

4 (14.8)

1

1

1

 AT

663 (11.5)

1.02 (0.89–1.18)

1.02 (0.89–1.18)

1.03 (0.89–1.19)

17 (16.8)

1.90 (0.66–5.49)

1.94 (0.67–5.61)

1.89 (0.65–5.52)

7 (13.0)

0.86 (0.23–3.23)

0.64 (0.16–2.65)

0.62 (0.14–2.7)

 AA

371 (12.1)

1.08 (0.92–1.27)

1.08 (0.92–1.27)

1.09 (0.93–1.28)

8 (18.6)

2.15 (0.65–7.13)

2.11 (0.63–7.02)

2.02 (0.60–6.82)

4 (10.8)

0.70 (0.16–3.08)

0.55 (0.12–2.61)

0.52 (0.10–2.60)

P for A

 

0.342

0.340

0.302

 

0.054

0.072

0.061

 

0.632

0.464

0.437

Rs11030104

 GG

330 (10.8)

1

1

1

7 (14.6)

1

1

1

5 (17.2)

1

1

1

 AG

700 (12.0)

1.13 (0.98–1.29)

1.13 (0.98–1.29)

1.13 (0.98–1.3)

17 (15.3)

1.06 (0.41–2.75)

1.10 (0.42–2.87)

1.08 (0.41–2.84)

6 (10.9)

0.59 (0.16–2.12)

0.38 (0.09–1.53)

0.29 (0.07–1.32)

 AA

316 (11.7)

1.10 (0.93–1.29)

1.10 (0.93–1.29)

1.10 (0.93–1.29)

6 (16.2)

1.13 (0.35–3.71)

1.13 (0.34–3.71)

1.12 (0.34–3.71)

4 (11.8)

0.64 (0.16–2.65)

0.46 (0.10–2.10)

0.40 (0.08–1.98)

P for A

 

0.258

0.257

0.254

 

0.836

0.835

0.852

 

0.537

0.340

0.296

Rs6484320

 TT

318 (10.8)

1

1

1

7 (13.7)

1

1

1

5 (17.9)

1

1

1

 TA

700 (12.0)

1.13 (0.98–1.30)

1.13 (0.98–1.30)

1.13 (0.98–1.30)

15 (14.9)

1.10 (0.42–2.89)

1.15 (0.43–3.07)

1.19 (0.44–3.21)

6 (10.5)

0.54 (0.15–1.96)

0.35 (0.09–1.42)

0.28 (0.06–1.25)

 AA

328 (11.7)

1.09 (0.93–1.29)

1.09 (0.93–1.29)

1.10 (0.93–1.29)

8 (18.2)

1.40 (0.46–4.22)

1.40 (0.46–4.25)

1.37 (0.45–4.20)

4 (12.1)

0.63 (0.15–2.64)

0.43 (0.09–1.98)

0.38 (0.08–1.88)

P for A

 

0.282

0.281

0.267

 

0.555

0.549

0.581

 

0.530

0.304

0.270

Total

            

Rs6265

 AA

365 (10.8)

1

1

1

28 (8.4)

1

1

1

19 (7.3)

1

1

1

 GA

763 (11.8)

1.11 (0.97–1.27)

1.11 (0.97–1.26)

1.11 (0.97–1.27)

55 (8.9)

1.07 (0.66–1.72)

1.10 (0.68–1.77)

1.09 (0.67–1.75)

34 (7.0)

0.97 (0.54–1.73)

0.94(0.52–1.68)

0.93 (0.52–1.67)

 GG

342 (11.4)

1.07 (0.91–1.25)

1.07 (0.91–1.25)

1.07 (0.91–1.25)

38 (13.7)

1.74 (1.04–2.91)

1.79 (1.07–3.01)

1.79 (1.06–3.01)

20 (8.3)

1.16 (0.60–2.23)

1.11 (0.52–2.14)

1.10 (0.57–2.13)

P for G

 

0.378

0.389

0.382

 

0.034*

0.027*

0.027*

 

0.664

0.761

0.775

Rs4923457

 TT

346 (11.3)

1

1

1

25 (8.0)

1

1

1

14 (6.2)

1

1

1

 AT

737 (11.5)

1.12 (0.89–1.17)

1.02 (0.89–1.17)

1.03 (0.90–1.18)

54 (8.9)

1.13 (0.69–1.86)

1.14 (0.70–1.88)

1.13 (0.69–1.86)

37 (7.7)

1.27 (0.67–2.41)

1.26 (0.67–2.39)

1.26 (0.67–2.39)

 AA

387 (11.4)

1.01 (0.87–1.18)

1.01 (0.87–1.18)

1.02 (0.87–1.19)

42 (13.4)

1.79 (1.06–3.02)

1.87 (1.11–3.16)

1.87 (1.10–3.16)

22 (7.8)

1.29 (0.65–2.59)

1.26 (0.63–2.54)

1.28 (0.63–2.57)

P for A

0.863

0.866

0.806

 

0.015**

0.022**

0.015**

 

0.496

0.540

0.522

Rs11030104

 GG

368 (10.8)

1

1

1

26 (8.1)

1

1

1

20 (7.5)

1

1

1

 AG

771 (11.9)

1.12 (0.98–1.28)

1.12 (0.98–1.28)

1.12 (0.98–1.28)

59 (9.2)

1.15 (0.71–1.87)

1.15 (0.71–1.87)

1.14 (0.70–1.85)

32 (6.7)

0.88 (0.49–1.57)

0.86 (0.48–1.54)

0.85 (0.47–1.52)

 AA

331 (11.1)

1.04 (0.89–1.21)

1.03 (0.88–1.21)

1.04 (0.88–1.21)

36 (13.4)

1.76 (1.03–3.00)

1.81 (1.06–3.10)

1.81 (1.06–3.10)

21 (8.6)

1.15 (0.61–2.18)

1.10 (0.58–2.10)

1.10 (0.58–2.09)

P for A

0.609

0.623

0.615

 

0.036*

0.028*

0.028*

 

0.675

0.765

0.782

Rs6484320

 TT

355 (10.8)

1

1

1

28 (8.6)

1

1

1

18 (7.1)

1

1

1

 TA

771 (11.9)

1.12 (0.98–1.28)

1.12 (0.98–1.28)

1.12 (0.98–1.28)

56 (9.0)

1.05 (0.66–1.69)

1.07 (0.66–1.72)

1.06 (0.66–1.71)

35 (7.2)

1.00 (0.56–1.81)

0.98 (0.54–1.78)

0.98 (0.54–1.78)

 AA

344 (11.1)

1.03 (0.88–1.21)

1.03 (0.88–1.20)

1.03 (0.88–1.21)

37 (12.8)

1.56 (0.93–2.63)

1.59 (0.95–2.68)

1.56 (0.94–2.67)

20 (8.1)

1.15 (0.59–2.22)

1.11 (0.57–2.16)

1.11 (0.57–2.17)

P for A

 

0.686

0.697

0.671

 

0.087

0.077

0.079

 

0.685

0.753

0.758

  1. ‡General obesity was defined as a body mass index (BMI) ≥ 28 kg/m2 using the criteria for the Asian population
  2. Model A: Crude model
  3. Model B: Adjusted for age, sex
  4. Model C: Adjusted for age, sex, education, income level and physical activity
  5. *: P < 0.05
  6. **: P < 0.025