From: Brain-derived neurotrophic factor gene variants and obesity in former smokers
 |  | Never smokers |  | Former smokers |  | Current smokers | ||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|
Male | General obesity‡ n(%) | Model A | Model B | Model C | Cases | Model A | Model B | Model C | Cases | Model A | Model B | Model C |
Rs6265 | ||||||||||||
 AA | 37 (10.4) | 1 | 1 | 1 | 21 (7.5) | 1 | 1 | 1 | 14 (5.9) | 1 | 1 | 1 |
 GA | 72 (11.6) | 1.13 (0.74–1.72) | 1.11 (0.73–1.69) | 1.11 (0.73–1.69) | 39 (7.5) | 1.00 (0.58–1.74) | 1.02 (0.59–1.77) | 1.01 (0.58–1.76) | 27 (6.3) | 1.07 (0.55–2.09) | 1.08 (0.55–2.09) | 1.07 (0.55–2.08) |
 GG | 15 (5.3) | 0.48 (0.26–0.90) | 0.48 (0.26–0.89) | 0.48 (0.26–0.89) | 31 (13.0) | 1.85 (1.03–3.31) | 1.88 (1.05–3.37) | 1.87 (1.04–3.36) | 17 (8.2) | 1.42 (0.68–2.95) | 1.42 (0.68–2.96) | 1.39 (0.67–2.91) |
P for G | Â | 0.049 | 0.043 | 0.044 | Â | 0.024** | 0.03* | 0.014** | Â | 0.348 | 0.346 | 0.379 |
Rs4923457 | ||||||||||||
 TT | 34 (11.3) | 1 | 1 | 1 | 20 (7.6) | 1 | 1 | 1 | 10 (5.0) | 1 | 1 | 1 |
 AT | 74 (11.4) | 1.01 (0.66–1.56) | 0.99 (0.64–1.53) | 0.99 (0.64–1.53) | 37 (7.3) | 0.96 (0.54–1.68) | 0.97 (0.55–1.70) | 0.96 (0.54–1.69) | 30 (7.1) | 1.44 (0.69–3.01) | 1.45 (0.69–3.03) | 1.44 (0.69–3.01) |
 AA | 16 (5.1) | 0.42 (0.23–0.78) | 0.42 (0.23–0.78) | 0.42 (0.23–0.78) | 34 (12.6) | 1.74 (1.01–3.12) | 1.79 (1.00–3.20) | 1.79 (1.00–3.20) | 18 (7.4) | 1.51 (0.68–3.36) | 1.52 (0.68–3.37) | 1.50 (0.67–3.33) |
P for A | Â | 0.010** | 0.019** | 0.015** | Â | 0.012** | 0.011** | 0.009** | Â | 0.335 | 0.333 | 0.351 |
Rs11030104 | ||||||||||||
 GG | 38 (10.6) | 1 | 1 | 1 | 19 (6.9) | 1 | 1 | 1 | 15 (6.4) | 1 | 1 | 1 |
 AG | 71 (11.3) | 1.07 (0.70–1.62) | 1.05 (0.69–1.59) | 1.05 (0.69–1.6) | 42 (7.9) | 1.15 (0.66–2.02) | 1.17 (0.67–2.06) | 1.16 (0.66–2.04) | 26 (6.2) | 0.97 (0.50–1.87) | 0.97 (0.50–1.87) | 0.96 (0.50–1.85) |
 AA | 15 (5.4) | 0.48 (0.26–0.89) | 0.48 (0.26–0.88) | 0.48 (0.26–0.89) | 30 (12.9) | 1.99 (1.09–3.65) | 2.04 (1.11–3.73) | 2.04 (1.11–3.73) | 17 (8.1) | 1.29 (0.63–2.65) | 1.29 (0.63–2.66) | 1.26 (0.61–2.61) |
P for A | Â | 0.043* | 0.011** | 0.039* | Â | 0.021** | 0.018** | 0.018** | Â | 0.487 | 0.483 | 0.530 |
Rs6484320 | ||||||||||||
 TT | 37 (10.9) | 1 | 1 | 1 | 21 (7.7) | 1 | 1 | 1 | 13 (5.8) | 1 | 1 | 1 |
 TA | 71 (11.2) | 1.03 (0.68–1.57) | 1.02 (0.67–1.55) | 1.01 (0.66–1.55) | 41 (7.9) | 1.03 (0.60–1.79) | 1.04 (0.60–1.81) | 1.04 (0.60–1.80) | 29 (6.7) | 1.17 (0.60–2.3) | 1.17 (0.60–2.31) | 1.17 (0.60–2.30) |
 AA | 16 (5.5) | 0.47 (0.26–0.87) | 0.47 (0.25–0.86) | 0.47 (0.25–0.86) | 29 (11.9) | 1.63 (0.90–2.93) | 1.65 (0.91–2.98) | 1.65 (0.91–2.97) | 16 (7.5) | 1.31 (0.62–2.8) | 1.31 (0.62–2.8) | 1.29 (0.60–2.76) |
P for A | Â | 0.029* | 0.025* | 0.025* | Â | 0.099 | 0.091 | 0.092 | Â | 0.483 | 0.482 | 0.516 |
Female | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Rs6265 | ||||||||||||
 AA | 328 (10.8) | 1 | 1 | 1 | 7 (12.7) | 1 | 1 | 1 | 5 (19.2) | 1 | 1 | 1 |
 GA | 691 (11.8) | 1.11 (0.96–1.27) | 1.11 (0.96–1.27) | 1.11 (0.96–1.27) | 16 (15.8) | 1.29 (0.5–3.36) | 1.37 (0.52–3.62) | 1.36 (0.51–3.64) | 7 (12.1) | 0.58 (0.16–2.02) | 0.39 (0.10–1.51) | 0.29 (0.07–1.27) |
 GG | 327 (12.1) | 1.13 (0.96–1.33) | 1.13 (0.96–1.33) | 1.13 (0.96–1.34) | 7 (17.5) | 1.46 (0.47–4.54) | 1.45 (0.46–4.52) | 1.47 (0.46–4.64) | 3 (8.8) | 0.41 (0.09–1.89) | 0.32 (0.06–1.61) | 0.26 (0.05–1.43) |
P for G | Â | 0.131 | 0.131 | 0.126 | Â | 0.051 | 0.062 | 0.053 | Â | 0.142 | 0.166 | 0.130 |
Rs4923457 | ||||||||||||
 TT | 312 (11.3) | 1 | 1 | 1 | 5 (9.6) | 1 | 1 | 1 | 4 (14.8) | 1 | 1 | 1 |
 AT | 663 (11.5) | 1.02 (0.89–1.18) | 1.02 (0.89–1.18) | 1.03 (0.89–1.19) | 17 (16.8) | 1.90 (0.66–5.49) | 1.94 (0.67–5.61) | 1.89 (0.65–5.52) | 7 (13.0) | 0.86 (0.23–3.23) | 0.64 (0.16–2.65) | 0.62 (0.14–2.7) |
 AA | 371 (12.1) | 1.08 (0.92–1.27) | 1.08 (0.92–1.27) | 1.09 (0.93–1.28) | 8 (18.6) | 2.15 (0.65–7.13) | 2.11 (0.63–7.02) | 2.02 (0.60–6.82) | 4 (10.8) | 0.70 (0.16–3.08) | 0.55 (0.12–2.61) | 0.52 (0.10–2.60) |
P for A | Â | 0.342 | 0.340 | 0.302 | Â | 0.054 | 0.072 | 0.061 | Â | 0.632 | 0.464 | 0.437 |
Rs11030104 | ||||||||||||
 GG | 330 (10.8) | 1 | 1 | 1 | 7 (14.6) | 1 | 1 | 1 | 5 (17.2) | 1 | 1 | 1 |
 AG | 700 (12.0) | 1.13 (0.98–1.29) | 1.13 (0.98–1.29) | 1.13 (0.98–1.3) | 17 (15.3) | 1.06 (0.41–2.75) | 1.10 (0.42–2.87) | 1.08 (0.41–2.84) | 6 (10.9) | 0.59 (0.16–2.12) | 0.38 (0.09–1.53) | 0.29 (0.07–1.32) |
 AA | 316 (11.7) | 1.10 (0.93–1.29) | 1.10 (0.93–1.29) | 1.10 (0.93–1.29) | 6 (16.2) | 1.13 (0.35–3.71) | 1.13 (0.34–3.71) | 1.12 (0.34–3.71) | 4 (11.8) | 0.64 (0.16–2.65) | 0.46 (0.10–2.10) | 0.40 (0.08–1.98) |
P for A | Â | 0.258 | 0.257 | 0.254 | Â | 0.836 | 0.835 | 0.852 | Â | 0.537 | 0.340 | 0.296 |
Rs6484320 | ||||||||||||
 TT | 318 (10.8) | 1 | 1 | 1 | 7 (13.7) | 1 | 1 | 1 | 5 (17.9) | 1 | 1 | 1 |
 TA | 700 (12.0) | 1.13 (0.98–1.30) | 1.13 (0.98–1.30) | 1.13 (0.98–1.30) | 15 (14.9) | 1.10 (0.42–2.89) | 1.15 (0.43–3.07) | 1.19 (0.44–3.21) | 6 (10.5) | 0.54 (0.15–1.96) | 0.35 (0.09–1.42) | 0.28 (0.06–1.25) |
 AA | 328 (11.7) | 1.09 (0.93–1.29) | 1.09 (0.93–1.29) | 1.10 (0.93–1.29) | 8 (18.2) | 1.40 (0.46–4.22) | 1.40 (0.46–4.25) | 1.37 (0.45–4.20) | 4 (12.1) | 0.63 (0.15–2.64) | 0.43 (0.09–1.98) | 0.38 (0.08–1.88) |
P for A | Â | 0.282 | 0.281 | 0.267 | Â | 0.555 | 0.549 | 0.581 | Â | 0.530 | 0.304 | 0.270 |
Total | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â | Â |
Rs6265 | ||||||||||||
 AA | 365 (10.8) | 1 | 1 | 1 | 28 (8.4) | 1 | 1 | 1 | 19 (7.3) | 1 | 1 | 1 |
 GA | 763 (11.8) | 1.11 (0.97–1.27) | 1.11 (0.97–1.26) | 1.11 (0.97–1.27) | 55 (8.9) | 1.07 (0.66–1.72) | 1.10 (0.68–1.77) | 1.09 (0.67–1.75) | 34 (7.0) | 0.97 (0.54–1.73) | 0.94(0.52–1.68) | 0.93 (0.52–1.67) |
 GG | 342 (11.4) | 1.07 (0.91–1.25) | 1.07 (0.91–1.25) | 1.07 (0.91–1.25) | 38 (13.7) | 1.74 (1.04–2.91) | 1.79 (1.07–3.01) | 1.79 (1.06–3.01) | 20 (8.3) | 1.16 (0.60–2.23) | 1.11 (0.52–2.14) | 1.10 (0.57–2.13) |
P for G | Â | 0.378 | 0.389 | 0.382 | Â | 0.034* | 0.027* | 0.027* | Â | 0.664 | 0.761 | 0.775 |
Rs4923457 | ||||||||||||
 TT | 346 (11.3) | 1 | 1 | 1 | 25 (8.0) | 1 | 1 | 1 | 14 (6.2) | 1 | 1 | 1 |
 AT | 737 (11.5) | 1.12 (0.89–1.17) | 1.02 (0.89–1.17) | 1.03 (0.90–1.18) | 54 (8.9) | 1.13 (0.69–1.86) | 1.14 (0.70–1.88) | 1.13 (0.69–1.86) | 37 (7.7) | 1.27 (0.67–2.41) | 1.26 (0.67–2.39) | 1.26 (0.67–2.39) |
 AA | 387 (11.4) | 1.01 (0.87–1.18) | 1.01 (0.87–1.18) | 1.02 (0.87–1.19) | 42 (13.4) | 1.79 (1.06–3.02) | 1.87 (1.11–3.16) | 1.87 (1.10–3.16) | 22 (7.8) | 1.29 (0.65–2.59) | 1.26 (0.63–2.54) | 1.28 (0.63–2.57) |
P for A | 0.863 | 0.866 | 0.806 | Â | 0.015** | 0.022** | 0.015** | Â | 0.496 | 0.540 | 0.522 | |
Rs11030104 | ||||||||||||
 GG | 368 (10.8) | 1 | 1 | 1 | 26 (8.1) | 1 | 1 | 1 | 20 (7.5) | 1 | 1 | 1 |
 AG | 771 (11.9) | 1.12 (0.98–1.28) | 1.12 (0.98–1.28) | 1.12 (0.98–1.28) | 59 (9.2) | 1.15 (0.71–1.87) | 1.15 (0.71–1.87) | 1.14 (0.70–1.85) | 32 (6.7) | 0.88 (0.49–1.57) | 0.86 (0.48–1.54) | 0.85 (0.47–1.52) |
 AA | 331 (11.1) | 1.04 (0.89–1.21) | 1.03 (0.88–1.21) | 1.04 (0.88–1.21) | 36 (13.4) | 1.76 (1.03–3.00) | 1.81 (1.06–3.10) | 1.81 (1.06–3.10) | 21 (8.6) | 1.15 (0.61–2.18) | 1.10 (0.58–2.10) | 1.10 (0.58–2.09) |
P for A | 0.609 | 0.623 | 0.615 | Â | 0.036* | 0.028* | 0.028* | Â | 0.675 | 0.765 | 0.782 | |
Rs6484320 | ||||||||||||
 TT | 355 (10.8) | 1 | 1 | 1 | 28 (8.6) | 1 | 1 | 1 | 18 (7.1) | 1 | 1 | 1 |
 TA | 771 (11.9) | 1.12 (0.98–1.28) | 1.12 (0.98–1.28) | 1.12 (0.98–1.28) | 56 (9.0) | 1.05 (0.66–1.69) | 1.07 (0.66–1.72) | 1.06 (0.66–1.71) | 35 (7.2) | 1.00 (0.56–1.81) | 0.98 (0.54–1.78) | 0.98 (0.54–1.78) |
 AA | 344 (11.1) | 1.03 (0.88–1.21) | 1.03 (0.88–1.20) | 1.03 (0.88–1.21) | 37 (12.8) | 1.56 (0.93–2.63) | 1.59 (0.95–2.68) | 1.56 (0.94–2.67) | 20 (8.1) | 1.15 (0.59–2.22) | 1.11 (0.57–2.16) | 1.11 (0.57–2.17) |
P for A | Â | 0.686 | 0.697 | 0.671 | Â | 0.087 | 0.077 | 0.079 | Â | 0.685 | 0.753 | 0.758 |