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Table 3 Odds ratios (95%CI) of central obesity for different SNPs in different smoke exposure groups

From: Brain-derived neurotrophic factor gene variants and obesity in former smokers

  

Never smokers

 

Former smokers

 

Current smokers

Male

Central obesity‡ n(%)

Model A

Model B

Model C

Cases

Model A

Model B

Model C

Cases

Model A

Model B

Model C

Rs6265

 AA

101 (28.3)

1

1

1

75 (26.8)

1

1

1

66 (28.0)

1

1

1

 GA

184 (29.6)

1.07 (0.80–1.42)

1.06 (0.80–1.42)

1.06 (0.80–1.42)

173 (33.3)

1.37 (0.99–1.89)

1.37 (1.00–1.90)*

1.39 (1.01–1.92)*

97 (22.8)

0.76 (0.53–1.09)

0.76 (0.53–1.10)

0.76 (0.53–1.10)

 GG

86 (30.3)

1.10 (0.78–1.55)

1.10 (0.78–1.55)

1.11 (0.79–1.56)

104 (43.7)

2.12 (1.47–3.07)**

2.13 (1.47–3.08)**

2.15 (1.49–3.12)**

56 (27.1)

0.96 (0.63–1.45)

0.96 (0.63–1.46)

0.95 (0.62–1.44)

P for G

 

0.575

0.579

0.553

 

< 0.001**

< 0.001**

< 0.001**

 

0.768

0.780

0.738

Rs4923457

 TT

90 (29.9)

1

1

1

74 (28.2)

1

1

1

49 (24.5)

1

1

1

 AT

191 (29.4)

0.98 (0.73–1.32)

0.98 (0.72–1.32)

0.98 (0.73–1.32)

171 (33.9)

1.30 (0.94–1.80)

1.30 (0.94–1.81)

1.32 (0.95–1.83)

104 (24.5)

1.00 (0.68–1.48)

1.01 (0.68–1.49)

1.01 (0.68–1.49)

 AA

90 (28.8)

0.95 (0.67–1.34)

0.95 (0.67–1.34)

0.95 (0.67–1.35)

107 (39.6)

1.67 (1.16–2.40)**

1.68 (1.17–2.41)**

1.70 (1.18–2.44)**

66 (27.0)

1.14 (0.74–1.75)

1.15 (0.75–1.77)

1.14 (0.74–1.75)

P for A

 

0.755

0.754

0.787

 

< 0.001**

0.005**

0.004**

 

0.517

0.500

0.530

Rs11030104

 GG

102 (28.6)

1

1

1

75 (27.4)

1

1

1

64 (27.1)

1

1

1

 AG

184 (29.3)

1.03 (0.78–1.38)

1.03 (0.78–1.38)

1.03 (0.77–1.38)

175 (33.0)

1.30 (0.95–1.8)

1.31 (0.95–1.81)

1.33 (0.96–1.84)

99 (23.5)

0.82 (0.57–1.19)

0.83 (0.58–1.19)

0.83 (0.58–1.20)

 AA

85 (30.7)

1.11 (0.79–1.56)

1.11 (0.78–1.56)

1.11 (0.79–1.57)

102 (44.0)

2.08 (1.44–3.02)**

2.10 (1.44–3.04)**

2.13 (1.47–3.09)**

56 (26.5)

0.97 (0.64–1.48)

0.98 (0.64–1.49)

0.97 (0.64–1.48)

P for A

 

0.569

0.573

0.554

 

< 0.001**

< 0.001**

< 0.001**

 

0.853

0.882

0.844

Rs6484320

 TT

95 (28.0)

1

1

1

75 (27.4)

1

1

1

64 (28.6)

1

1

1

 TA

184 (29.1)

1.06 (0.79–1.41)

1.05 (0.79–1.41)

1.05 (0.78–1.41)

176 (33.9)

1.36 (0.99–1.88)

1.37 (0.99–1.88)

1.38 (1.00–1.91)*

98 (22.7)

0.74 (0.51–1.06)

0.74 (0.51–1.07)

0.74 (0.51–1.07)

 AA

92 (31.5)

1.18 (0.84–1.66)

1.18 (0.84–1.66)

1.18 (0.84–1.67)

101 (41.4)

1.87 (1.30–2.71)**

1.88 (1.30–2.72)**

1.90 (1.31–2.75)**

57 (26.6)

0.91 (0.60–1.38)

0.91 (0.60–1.38)

0.90 (0.59–1.37)

P for A

 

0.344

0.347

0.340

 

0.001**

0.001**

0.001**

 

0.622

0.626

0.587

Female

            

Rs6265

 AA

1697 (55.9)

1

1

1

36 (65.5)

1

1

1

17 (65.4)

1

1

1

 GA

3408 (58.3)

1.10 (1.01–1.20)*

1.10 (1.01–1.20)*

1.10 (1.01–1.21)*

74 (73.3)

1.45 (0.71–2.94)

1.46 (0.71–2.99)

1.45 (0.70–2.99)

32 (55.2)

0.65 (0.25–1.70)

0.61 (0.23–1.63)

0.60 (0.22–1.61)

 GG

1614 (59.6)

1.16 (1.05–1.29)*

1.16 (1.04–1.29)*

1.17 (1.05–1.30)*

30 (75.0)

1.58 (0.64–3.92)

1.58 (0.64–3.91)

1.62 (0.65–4.03)

18 (52.9)

0.6 (0.21–1.71)

0.57 (0.20–1.65)

0.56 (0.19–1.64)

P for G

 

0.005**

0.006**

0.004**

 

0.283

0.283

0.268

 

0.355

0.326

0.319

Rs4923457

 TT

1578 (57.1)

1

1

1

34 (65.4)

1

1

1

18 (66.7)

1

1

1

 AT

3325 (57.8)

1.03 (0.94–1.13)

1.03 (0.94–1.13)

1.03 (0.94–1.14)

73 (72.3)

1.38 (0.67–2.83)

1.38 (0.67–2.84)

1.42 (0.68–2.93)

29 (53.7)

0.58 (0.22–1.52)

0.56 (0.21–1.47)

0.56 (0.21–1.49)

 AA

1816 (59.1)

1.09 (0.98–1.21)

1.08 (0.97–1.20)

1.09 (0.98–1.21)

33 (76.7)

1.75 (0.70–4.34)

1.74 (0.70–4.33)

1.83 (0.73–4.60)

20 (54.1)

0.59 (0.21–1.65)

0.56 (0.20–1.59)

0.57 (0.20–1.64)

P for A

 

0.115

0.142

0.101

 

0.218

0.220

0.186

 

0.351

0.319

0.327

Rs11030104

 GG

1714 (56.1)

1

1

1

34 (70.8)

1

1

1

18 (62.1)

1

1

1

 AG

3401 (58.3)

1.09 (1.00–1.19)

1.09 (1.00–1.19)

1.09 (1.00–1.20)

78 (70.3)

0.97 (0.46–2.05)

0.98 (0.46–2.06)

0.99 (0.46–2.09)

29 (52.7)

0.68 (0.27–1.71)

0.64 (0.25–1.63)

0.64 (0.25–1.66)

 AA

1604 (59.5)

1.15 (1.03–1.27)*

1.14 (1.03–1.27)*

1.15 (1.03–1.28)*

28 (75.7)

1.28 (0.48–3.40)

1.28 (0.48–3.4)

1.31 (0.49–3.49)

20 (58.8)

0.87 (0.32–2.41)

0.82 (0.29–2.31)

0.85 (0.30–2.42)

P for A

 

0.010**

0.012**

0.01**

 

0.655

0.655

0.628

 

0.831

0.768

0.805

Rs6484320

 TT

1658 (56.2)

1

1

1

35 (68.6)

1

1

1

19 (67.9)

1

1

1

 TA

3404 (58.4)

1.10 (1.00–1.20)

1.10 (1.00–1.20)

1.10 (1.00–1.20)

74 (73.3)

1.25 (0.60–2.62)

1.27 (0.60–2.66)

1.30 (0.62–2.76)

30 (52.6)

0.53 (0.20–1.36)

0.48 (0.18–1.28)

0.49 (0.18–1.30)

 AA

1657 (58.9)

1.12 (1.01–1.24)*

1.12 (1.00–1.24)*

1.12 (1.01–1.25)*

31 (70.5)

1.09 (0.45–2.62)

1.09 (0.45–2.62)

1.10 (0.46–2.67)

18 (54.5)

0.57 (0.20–1.62)

0.52 (0.18–1.53)

0.52 (0.18–1.57)

P for A

 

0.034*

0.040*

0.033*

 

0.820

0.819

0.802

 

0.322

0.273

0.281

Total

            

Rs6265

 AA

1798 (53.0)

1

1

1

111 (33.1)

1

1

1

83 (31.7)

1

1

1

 GA

3592 (55.5)

1.11*

1.10*

1.10*

247 (39.8)

1.34*

1.39*

1.39*

129 (26.7)

0.78

0.75

0.75

(1.02–1.20)

(1.01–1.20)

(1.01–1.20)

(1.01–1.77)

(1.03–1.86)

(1.04–1.87)

(0.56–1.09)

(0.54–1.06)

(0.54–1.06)

 GG

1700 (56.8)

1.16**

1.15**

1.16**

134 (48.2)

1.88**

2.06**

2.08**

74 (30.7)

0.96

0.90

0.89

(1.05–1.29)

(1.04–1.28)

(1.05–1.28)

(1.35–2.61)

(1.46–2.90)

(1.47–2.92)

(0.66–1.39)

(0.61–1.32)

(0.60–1.32)

P for G

 

0.002**

0.005**

0.004**

 

< 0.001**

< 0.001**

< 0.001**

 

0.774

0.547

0.524

Rs4923457

 TT

1668 (54.4)

1

1

1

108 (34.4)

1

1

1

67 (29.5)

1

1

1

 AT

3576 (54.9)

1.02

1.02

1.03

244 (40.3)

1.29

1.32

1.33

133 (27.8)

0.92

0.93

0.93

(0.94–1.11)

(0.94–1.12)

(0.94–1.13)

(0.97–1.71)

(0.98–1.77)

(0.99–1.79)

(0.65–1.30)

(0.65–1.33)

(0.65–1.33)

 AA

1906 (56.3)

1.01

1.07

1.08

140 (44.7)

1.54**

1.69**

1.70**

86 (30.6)

1.05

1.04

1.04

(0.87–1.18)

(0.97–1.18)

(0.98–1.19)

(1.12–2.13)

(1.21–2.37)

(1.22–2.39)

(0.72–1.54)

(0.70–1.55)

(0.70–1.54)

P for A

 

0.124

0.185

0.137

 

0.008**

0.002**

0.002**

 

0.742

0.793

0.814

Rs11030104

 GG

1816 (53.2)

1

1

1

109 (33.9)

1

1

1

82 (30.9)

1

1

1

 AG

3585 (55.5)

1.09*

1.09*

1.09*

253 (39.4)

1.27

1.25

1.26

128 (26.8)

0.82

0.81

0.81

(1.01–1.19)

(1.00–1.18)

(1.00–1.19)

(0.96–1.68)

(0.93–1.68)

(0.94–1.70)

(0.59–1.14)

(0.58–1.14)

(0.58–1.14)

 AA

1689 (56.8)

1.15**

1.14**

1.15**

130 (48.3)

1.83**

1.96** (1.39–2.78)

1.99**

76 (31.0)

1.00

0.97

0.96

(1.05–1.27)

(1.03–1.26)

(1.04–1.27)

(1.31–2.55)

(1.41–2.81)

(0.69–1.46)

(0.66–1.42)

(0.65–1.42)

P for A

 

0.004**

0.009**

0.008**

 

< 0.001**

< 0.001**

< 0.001**

 

0.984

0.838

0.815

Rs6484320

 TT

1753 (53.3)

1

1

1

110 (33.8)

1

1

1

83 (32.9)

1

1

1

 TA

3588 (55.6)

1.10*

1.09*

1.09

250 (40.3)

1.32*

1.35*

1.36*

128 (26.2)

0.72

0.71

0.71

(1.01–1.19)

(1.00–1.19)

(1.00–1.19)

(1.00–1.75)

(1.00–1.80)

(1.01–1.82)

(0.52–1.01)

(0.51–1.00)

(0.51–1.00)

 AA

1749 (56.3)

1.13**

1.12**

1.13**

132 (45.8)

1.65**

1.74**

1.75**

75 (30.4)

0.89

0.86

0.85

(1.03–1.25)

(1.02–1.24)

(1.02–1.25)

(1.19–2.29)

(1.24–2.45)

(1.25–2.47)

(0.61–1.30)

(0.58–1.26)

(0.58–1.26)

P for A

 

0.013**

0.024**

0.019**

 

0.002**

0.001**

0.001**

 

0.518

0.418

0.397

  1. ‡Central obesity was based on the criteria for the Asian population (waist circumference [WC] ≥ 90 cm in men and ≥ 80 cm in women)
  2. Model A: Crude model
  3. Model B: Adjusted for age, sex
  4. Model C: Adjusted for age, sex, education, income level and physical activity
  5. *: P < 0.05
  6. **: P < 0.025
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