Up-regulation of apoptotic- and cell survival-related gene pathways following exposures of western corn rootworm to B. thuringiensis crystalline pesticidal proteins in transgenic maize roots

Table 4 Count of differentially expressed transcripts between treatment pairs (FDR ≤ 0.05 in DESeq2 and EdgeR)

	ID/Treatment (as in Table 2)
	T7-T8	T7-T5	T7-T3	T7-T6
Transcript partitions	Cn v. VT3	Cn s. Hx	Cn v. Ma	Cn v. Hb
Total differentially expressed	1064	1387	1199	1562
total up-regulated	950	1296	638	1269
total down-regulated	114	91	563	293
total with PFAM domains	773	1031	658	820
total with signal peptide	293	366	212	204
Endogenous* (total/Bt only)^#	1055/ 798	1374/1079	NA	NA
up-regulated (total/Bt only)^#	942/ 771	1291/1059	636/NA	1269/NA
down-regulated (total/Bt only)^#	113/ 27	83/ 20	563/NA	293/NA

* no significant BLASTx hits to Wolbachia, Heterorhabditis bacteriophora (Hb), or Metarhizium anisopliae (Ma) protein databases (E-values > 1.0^− 7)
# Bt only values obtained by filtering differentially expressed transcripts from Cry3Bb1 or Gpp34/Tpp35Ab1 datasets which were also differentially expressed in Hb and Ma treatments
NA Not applicable

ISSN: 1471-2164