Fig. 1
From: Distribution and diversity of dimetal-carboxylate halogenases in cyanobacteria
Selected examples of halogenation reactions catalyzed by different classes of microbial enzymes, with a focus on cyanobacterial halogenases. a Chlorination of carrier protein-bound or free-standing aliphatic substrates by the nonheme iron/2OG-dependent halogenases CurA and WelO5; b Chlorination and bromination of electron-rich substrates by the flavin-dependent halogenases PrnA, Bmp5 and McnD; c Chlorination of terminal or mid-chain alkyl positions by dimetal-carboxylate halogenases CylC, ColD/ColE, ClyC/ClyD and BrtJ. An asterisk denotes that the enzyme has been biochemically characterized. ACP – acyl carrier protein