Table 2 Top 20 genes with highest betweenness in network

apc

APC regulator of WNT signaling pathway

9

3

6

1

ubl3b

ubiquitin-like 3b

7

2

5

1

mapk7

mitogen-activated protein kinase 7

5

4

1

1

gata3

GATA binding protein 3

8

3

5

1

tfap2a

transcription factor AP-2 alpha

11

4

7

1

kdm5ba

lysine (K)-specific demethylase 5Ba

3

1

2

1

sf3b6

splicing factor 3b, subunit 6

3

2

1

1

pfklb

phosphofructokinase, liver b

5

1

4

1

kremen1

kringle containing transmembrane protein 1

14

4

10

2

cacna1da

calcium channel, voltage-dependent, L type, alpha 1D subunit, a

30

5

25

2

tfe3a

transcription factor binding to IGHM enhancer 3a

30

11

19

2

rusc1

RUN and SH3 domain containing 1

6

2

4

3

ppp2r3a

protein phosphatase 2, regulatory subunit B″, alpha

4

2

2

4

bhlhe23

basic helix-loop-helix family, member e23

19

8

11

4

fosl2

fos-like antigen 2

18

7

11

4

sgsm1a

small G protein signaling modulator 1a

11

5

6

7

ccdc43

coiled-coil domain containing 43

3

2

1

9

dimt1l

DIM1 dimethyladenosine transferase 1-like (S. cerevisiae)

5

3

2

9

g3bp1

GTPase activating protein (SH3 domain) binding protein 1

7

4

3

11

prr12a

proline rich 12a

7

7

0

12