Fig. 2

SCFA-related synthetic enzyme genes and harboring species in the gut of AF patients. (a) Box plots showing the relative abundance levels of seven short-chain fatty acids (SCFAs)-related synthetic enzyme genes. Boxes reflect interquartile ranges; lines and circles depict medians and outliers, respectively. The color of the block under each box denotes enrichment assessed by Log2 (Fold Change), with red and blue indicating enrichment in the atrial fibrillation (AF) cases and non-AF controls (CTR), respectively. The color of the star inside the block indicates the q value (q < 0.01, dark gray asterisk; q < 0.05, light gray asterisk; q ≥ 0.05, transparent asterisk; N.S., not significant;). (b) Density plot showing the relative number of species that harbored SCFA-related enzyme genes. (c) Stack bar plot depicting the relative abundance levels of the 10 species that harbored synthesis enzyme genes for SCFAs-related compounds; the color of the bar reflects a given species. The right panel is a chord diagram showing the links among the 10 species with spearman correlation |r|>0.15, where red and blue lines denoting positive and negative correlations, respectively. The blocks and stars have the same descriptions as in panel (a)