Table 2 Different phenotypic approaches used to analyse CHD in GWAS
Approach | Phenotype for GWAS |
|---|---|
Single populations | |
UK HS | Total hip score |
UK FCI | HS converted to FCI* |
UK case-control | Cases (BVA/KC scores > = 11) vs. controls (scores 0–10) |
SWE FCI grades | FCI grades |
SWE case-control | Cases (FCI grades B-E) vs. controls (FCI grade A) |
FIN FCI grades | FCI grades |
FIN case-control | Cases (FCI grades B-E) vs. controls (FCI grade A) |
Meta-analysis | |
FCI grades | FCI grades with HS-transformed UK dogs* |
Case-control | Cases (FCI grades B-E for SWE and FIN, BVA/KC > =11 for UK) vs. controls (FCI grade A for SWE and FIN, scores 1–10 for UK) |