Fig. 2

Gene Ontology (GO) enrichment analysis of differentially expressed genes. Representative enriched GO terms are shown as dots for each GO category (Biological process, Cellular component, or Molecular function). The significantly differentially expressed genes in all pairwise comparisons (All comparisons, 455 genes), in the comparison between young and adult CNS transcriptomes (Young vs. Adult, 20,141 genes), young and old CNS transcriptomes (Young vs. Old, 18,394 genes), or adult and old CNS transcriptomes (Adult vs Old, 3108 genes) were used for the analysis. The dot size reflects the number of genes in the GO term for each significantly differentially expressed gene set; the dot colour represents the FDR-corrected p-value, with darker colours indicating lower p-values; the line size represents the degree of similarity. Abbreviations: met. = metabolic, pr. = process, neg. = negative, pos. = positive, reg. = regulation, mb = membrane, prot. = protein, chr = chromosome, RNAP II = RNA polymerase II, MT = mitochondrial, ECM = extracellular matrix