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Fig. 8 | BMC Genomics

Fig. 8

From: Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver disease

Fig. 8

The proposed schematic diagram of significant metabolic changes occurred in the pathogenesis of fatty liver disease in dairy cows. During the perinatal period, the metabolism of dairy cattle is in a state of negative energy balance, promoting the mobilization of fat in the liver. Enhanced fat mobilization promotes a sharp increase in non-esterified fatty acids (NEFA) in the liver. These NEFAs are more inclined to involved into re-esterification and therefore synthesis of triglycerides (TG) and/or production of ketone bodies, but not β-oxidation, because of motochrondrial dysfunction and inflammation causing the increased (red) and/or decreased (green) metabolism processes. The excessive accumulation of TG in the liver would lead to fatty liver

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