Fig. 8From: Proteome analysis identified proteins associated with mitochondrial function and inflammation activation crucially regulating the pathogenesis of fatty liver diseaseThe proposed schematic diagram of significant metabolic changes occurred in the pathogenesis of fatty liver disease in dairy cows. During the perinatal period, the metabolism of dairy cattle is in a state of negative energy balance, promoting the mobilization of fat in the liver. Enhanced fat mobilization promotes a sharp increase in non-esterified fatty acids (NEFA) in the liver. These NEFAs are more inclined to involved into re-esterification and therefore synthesis of triglycerides (TG) and/or production of ketone bodies, but not β-oxidation, because of motochrondrial dysfunction and inflammation causing the increased (red) and/or decreased (green) metabolism processes. The excessive accumulation of TG in the liver would lead to fatty liverBack to article page