Fig. 3

Phylogenetic relationships of TMD components of carbohydrate ABC transporters from species of Mycobacterium genus. A Phylogenetic tree of Mycobacterium carbohydrate TMD components. The tree was inferred using a Maximum likelihood method and Le-Gascuel (LG) amino acid substitution model in MEGA-X. Two trees are showed due to the separation of TMDs in two groups, each one with one member of each transporter. Group 1: SugB, Rv2039c, UspB, and UgpE, and Group 2: SugA, Rv2040c, UspA, and UgpA. Dark gray: M. tuberculosis complex group (MTBC), light gray: other pathogenic mycobacteria, and white: environmental species, represented by M. smegmatis. The amino acid sequences of TTH_RS04960 and TTH_RS04965 from Thermus thermophilus, encoding putative carbohydrate TMDs, were used as outgroup. B Structural models of SugB, Rv2039c, UspB, UgpE and SugA, Rv2040c, UspA, and UgpA highlighting the regions that showed significant variation in the amino acid sequences alignments (green colored spheres). Details of the model’s building is shown in the Additional file 1, Table S2