Fig. 4From: Comparison of the transcriptome in circulating leukocytes in early lactation between primiparous and multiparous cows provides evidence for age-related changesDavid functional annotation Cluster 6 contained genes involved in immunity which were more highly expressed in MP > 3 vs PP cows. This included genes encoding proteins for pattern recognition receptors (PRR), the bovine MHC complex, the complement system and several with antimicrobial activity. NRROS and TNFAIP8L2 can both act as negative regulators of TLR signalling mediated via inhibition of NF-kappa-B activationBack to article page