Fig. 4

Three-way enrichment Map showing gene set clusters (nodes) that were significantly enriched in DFTD tumors between pairs of localities. Node colors indicate which between-locality contrasts were enriched for gene sets within each cluster (e.g., clusters showing all three colors contain gene sets that were enriched in all three pairwise contrasts between localities). Node border colors indicate average normalized enrichment scores (NES) for gene sets in TKN tumors relative to BR tumors. Edges represent genes shared between gene sets from different clusters. Clusters are annotated and labelled according to the number of genes and gene sets they contain. Cluster annotations are derived from highly repeated words among gene set names