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Table 9 Role of different hub genes identified in rohu fish gonad

From: Revelation of candidate genes and molecular mechanism of reproductive seasonality in female rohu (Labeo rohita Ham.) by RNA sequencing

Gene Description Reference
ZGC gene family ZGC gene is involved in oocyte maturation and ovulation in zebrafish [116]
ZAR1 Zar1 is highly conserved gene also present in zebrafish, involved in growth of ovarian follicles [121]
NASP nuclear autoantigenic sperm protein: Expression of zona pellucida protein of primary oocytes and cell cycle regulation in zebrafish is associated with NASP gene. This gene is also reported to promote female development by repressing male-specific genes [122]
Col12A1: Collagen Type XII Alpha 1 Chain This is a signalling molecule associated with chondrocyte differentiation especially where collagen molecules are used in tissue remodeling during physiological growth and differentiation in zebrafish [123]
SCML4 (Sex Comb On Midleg Like) SCML4 is differentially expressed and its GRN study has revealed its role in development of optic, retina and olfactory epithelia with reproductive seasonality in teleost fish [124]
ptgdsb Prostaglandin D2 Synthase: This gene is involved in synthesis of prostaglandins which controls spawning by stimulating contraction of smooth muscles leading to ovulation in goldfish [125]
Col 6a3 Collagen Type VI Alpha 3 Chain;There is seasonal change in collagen content in muscles of fish synchronised with swimming ability. In farm fish,swimming exercise is reported to control puberty. [126, 127]
CDC42 gene Cell Division Cycle 42: Fish egg yolk mainly contains vitellogenins, synthesized in liver, growing oocytes takes it from circulation by receptor-mediated endocytosis in oocyte growth [128]
ACD Adrenocortical dysplasia homolog (ACD), Shelterin Complex Subunit And Telomerase Recruitment:
This gene controls telomeric elongation mediating mitogenic actions of estrogen in granulosa cells for ovarian growth with season
[129]