Early life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in rats

McKibben, Lauren Allen; Dwivedi, Yogesh

doi:10.1186/s12864-021-08003-4

Table 3 miRNAs significantly altered by MS and Enrichment

From: Early life and adult stress promote sex dependent changes in hypothalamic miRNAs and environmental enrichment prevents stress-induced miRNA and gene expression changes in rats

			CPM-Fold Change			p (one-way ANOVA)
Accession ID	Chromosomal Location	miRNA	MS:C	MS + Enr:C	MS + Enr:MS		sig.
upregulated by MS
MIMAT0017819	chr18: 56726128–56,726,240	miR-3557-5p	1.282	1.359	1.060	0.043	b,d,
MIMAT0000838	chr10: 62014995–62,015,095	miR-132-3p	1.278	1.394	1.091	0.000	a,b,d,f
MIMAT0003379	chr18: 56726150–56,726,214	miR-378a-3p	1.276	1.362	1.068	0.019	a,b,d,
MIMAT0026467	chr11: 16097346–16,097,433	miR-125b-2-3p	1.252	1.425	1.138	0.034	b,d,f
MIMAT0017158	chr10: 62014702–62,014,812	miR-212-5p	1.252	1.598	1.276	0.000	a,b,c,d,f
MIMAT0035730	chr13: 77065446–77,065,507	miR-1843b-5p	1.201	1.263	1.051	0.015	a,b,d,
MIMAT0000859	chr13: 54952903–54,953,012	miR-181b-5p	1.195	1.373	1.149	0.004	a,b,d,f
MIMAT0003205	chr6: 133893419–133,893,495	miR-409a-3p	1.176	1.324	1.125	0.000	a,b,d,f
MIMAT0000822	chr8: 45746948–45,747,027	miR-100-5p	1.176	1.436	1.221	0.002	b,d,f
MIMAT0000550	chr6: 133861199–133,861,284	miR-323-3p	1.163	1.275	1.097	0.001	a,b,d,f
MIMAT0000820	chr11: 16052153–16,052,233	miR-99a-5p	1.161	1.431	1.232	0.000	b,c,d,f
MIMAT0017163	chrX: 3684480–3,684,588	miR-221-5p	1.130	1.305	1.156	0.001	b,c,d,f
MIMAT0017217	chr6: 133699509–133,699,592	miR-493-5p	1.124	1.220	1.085	0.046	b,d,f
MIMAT0003202	chr6: 133884178–133,884,257	miR-382-3p	1.123	1.310	1.167	0.002	b,c,d,f
MIMAT0001626	chr6: 133711425–133,711,538	miR-431	1.118	1.225	1.096	0.002	a,b,d,f
MIMAT0000858	chr3: 23150352–23,150,468	miR-181a-5p	1.117	1.343	1.203	0.021	b,d,f
MIMAT0017123	chr10: 62014995–62,015,095	miR-132-5p	1.115	1.249	1.120	0.002	a,b,d,f
MIMAT0005299	chr19: 25290051–25,290,133	miR-181d-5p	1.113	1.399	1.257	0.000	b,c,d,f
MIMAT0003177	chr6: 133892655–133,892,744	miR-541-5p	1.108	1.265	1.142	0.012	b,d,f
MIMAT0005314	chr8: 117354821–117,354,903	miR-425-5p	1.105	1.239	1.121	0.023	b,d,f
MIMAT0003194	chr6: 133872439–133,872,522	miR-376c-3p	1.103	1.185	1.074	0.002	a,b,d,f
MIMAT0024843	chr1: 143360224–143,360,287	miR-1839-5p	1.103	1.237	1.122	0.014	b,d,f
MIMAT0017870	chr6: 133893418–133,893,497	miR-409b	1.101	1.173	1.065	0.045	b,d,f
MIMAT0003204	chr6: 133893419–133,893,495	miR-409a-5p	1.086	1.220	1.123	0.003	b,c,d,f
MIMAT0004706	chr1: 59704381–59,704,473	let-7e-3p	1.082	1.087	1.005	0.037	a,b,d,
MIMAT0004710	chr15: 100179879–100,179,962	miR-17-1-3p	1.069	1.212	1.134	0.001	b,c,d,f
MIMAT0003200	chr6: 133877124–133,877,205	miR-487b-3p	1.069	1.183	1.106	0.043	b,d,f
MIMAT0003207	chr6: 133893693–133,893,771	miR-369-3p	1.061	1.237	1.166	0.000	b,c,d,f
MIMAT0005282	chr5: 113657727–113,657,807	miR-872-5p	1.046	1.193	1.141	0.001	b,c,d,f
downregulated by MS
MIMAT0000850	chr10: 65291365–65,291,447	miR-144-3p	−1.783	−1.701	1.048	0.024	a,d,
MIMAT0017154	chr9: 26791764–26,791,847	miR-206-5p	−1.766	−1.707	1.035	0.008	a,b,d,
MIMAT0005445	chr4: 58344310–58,344,390	miR-29b-1-5p	−1.708	− 1.520	1.124	0.012	a,b,d,e,
MIMAT0005304	chr11: 88129426–88,129,503	miR-301b-3p	−1.564	− 1.335	1.171	0.036	a,d,e,
MIMAT0017230	chr10: 56844977–56,845,045	miR-497-3p	−1.386	−1.582	− 1.142	0.001	a,b,d,f
MIMAT0000889	chr20: 3816158–3,816,267	miR-219a-5p	−1.314	−1.504	− 1.144	0.010	b,d,f
MIMAT0000812	chr7: 123431612–123,431,680	miR-33-5p	−1.311	−1.620	− 1.235	0.003	a,b,d,f
MIMAT0001543	chr2: 44897601–44,897,691	miR-449a-5p	−1.251	−1.660	− 1.327	0.001	b,c,d,f
MIMAT0017839	chr10: 109195234–109,195,336	miR-3065-5p	−1.238	−1.139	1.087	0.045	a,d,
MIMAT0035720	chr8: 114874457–114,874,544	let-7 g-3p	−1.231	−1.288	− 1.046	0.017	a,b,d,
MIMAT0005328	chr6: 133691381–133,691,463	miR-673-5p	−1.210	−1.306	− 1.080	0.000	a,b,d,f
MIMAT0017143	chr2: 263873759–263,873,844	miR-186-3p	−1.205	−1.253	− 1.040	0.015	a,b,d,
MIMAT0017026	chr10: 74417746–74,417,845	miR-301a-5p	−1.203	−1.341	− 1.115	0.008	a,b,d,f
MIMAT0000805	chr5: 139702872–139,702,963	miR-30e-5p	−1.178	−1.238	− 1.052	0.007	a,b,d,f
MIMAT0004707	chr7: 66802731–66,802,815	let-7i-3p	−1.168	−1.326	− 1.135	0.006	b,d,f
MIMAT0000581	chr10: 109195251–109,195,316	miR-338-3p	−1.147	−1.277	− 1.113	0.024	b,d,f
MIMAT0017093	chr2: 165605923–165,606,020	miR-15b-3p	−1.144	−1.174	− 1.027	0.042	b,d,
MIMAT0000587	chr6: 133733240–133,733,335	miR-341	−1.131	−1.196	− 1.057	0.020	b,d,f
MIMAT0004732	chr7: 32894877–32,894,976	miR-135a-3p	−1.114	−1.189	− 1.068	0.007	b,d,f
MIMAT0000815	chr5: 167092491–167,092,592	miR-34a-5p	−1.090	−1.241	− 1.139	0.036	b,d,f
MIMAT0000570	chr7: 34881095–34,881,190	miR-331-3p	−1.067	−1.315	− 1.233	0.001	b,c,d,f

^a controls vs. MS
^b controls vs. MS + Enr
^c MS vs. MS + Enr
^d controls vs. MS and MS + Enr
^e controls and MS + Enr vs. MS (recovered by Enr)
^f controls and MS vs. MS + Enr
Significant changes in miRNA expression after MS and Enr based on one-way ANOVA are shown. Listed miRNAs are split by those upregulated vs. downregulated by MS. CPM-fold change value was calculated as a ratio between two group’s CPM expression. Positive values indicate increased expression and negative values show reduced expression in the numerator group. The full one-way ANOVA significance is listed as p. Specific group differences are listed as sig. Abbreviations: CPM-counts per million, MS-maternal separation, Enr-environmental enrichment, C-control

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