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Table 1 Pathogens detected by nanopore sequencing and culture, stratified by four methods

From: Combined nanopore adaptive sequencing and enzyme-based host depletion efficiently enriched microbial sequences and identified missing respiratory pathogens

Sample

Pathogen

SD_SSD

SD_ADS

HD_SSD

HD_ADS

Culture

P4

S. pneumoniae

4/2.0 ka

180.9 k/792.7 Mb

16/16.0 k

915 k/792.7 M

39/43.6 k

950.5 k/792.7 M

65/71.4 k

1484 k/792.7 M

Negative

P6

S. pneumoniae

20/14.1 k

48.7 k/74 M

38/27.5 k

137.8 k/74 M

503/470.2 k

63.1 k/74 M

557/504.1 k

80.2 k/74 M

Negative

P7

S. pneumoniae

1/331

40.8 k/168 M

4/1.7 k

152.6 k/168 M

363/308.0 k

159.5 k/168 M

531/439.8 k

261 k/168 M

S. dysgalactiae

H. parainfluenzae

0/0

7/15.0 k

333/323.8 k

538/535.2 k

S. dysgalactiae

1/4.0 k

8/10.1 k

1269/1.3 M

2102/2.1 M

P8

T. whipplei

13/20.9 k

35.6 k/195.7 M

28/96.8 k

72 k/195.7 M

15,951/21.5 M

162 K/195.7 M

26,929/36.1 M

276.5 K/195.7 M

Negative

  1. aNumber of reads / Number of bases for the pathogen
  2. bTotal number of reads / Total number of bases for the sample