Table 7 The gene-tissue pairs significantly associated with economically important traits from cGTEx (for iHS)

Milk yield

C2CD2-Embryo、GSKIP-Muscle、SNX33-Embryo

Protein yield

C2CD2-Embryo、GSKIP-Muscle、SNX33-Embryo、KIRREL3-Adipose、HES6-Intramuscular_fat

Protein percentage

C2CD2-Embryo、GTF3A-Embryo

Fat yield

C2CD2-Embryo、KIRREL3-Adipose

Mastitis

ETFA-Liver、ATP8A2-Liver、CIDEB-Blood、LTB4R-Blood、PTPN9-Muscle、MAN2C1-Blood、USP12-Intramuscular_fat

Sire conception rate

TRIM27-Macrophage、GSKIP-Muscle、RNF31-Milk_cell、ADCY4-Ileum、ATG2B-Liver、SDR39U1-Intramuscular_fat

Sire calving ease

RGS9-Blood、ARSG-Blood

Heifer conception rate

RPUSD4-Adipose

Age at first calving

CHMP4A-Blood、DCAF11-Blood、HP1BP3-Lymph_node、WIPI1-Jejunum

Days to first breeding after calving

GTF3A-Embryo、MGC134105-Liver

Daughter stillbirth

FLT1-Macrophage、RGS9-Blood、TCP1-Blood

Cow conception rate

EXOC4-Blood、MGC134105-Liver

Daughter pregnancy rate

TRIM27-Macrophage、EXOC4-Blood、CHMP4A-Blood、MGC134105-Liver、CAMK2N1-Blood

Daughter calving ease

PRKAR1A-Blood、RGS9-Blood、CBLN3-Adipose、KCNMB1-Blood

Under depth

ETFA-Liver、FLT1-Macrophage

Udder cleft

ETFA-Liver、TRIM27-Macrophage、FLT1-Macrophage

Teat length

PTPN9-Muscle

Strength

GTF3A-Embryo、FLT1-Macrophage、KIRREL3-Adipose、PRKAR1A-Blood

Stature

GTF3A-Embryo

Rump width

KIRREL3-Adipose、ST3GAL4-Blood、ARSG-Blood、FOXRED1-Blood

Rump angle

GTF3A-Embryo、GSKIP-Muscle

Retained placenta

C2CD2-Embryo、CHMP4A-Blood、MDP1-Blood、TMPRSS2-Mammary

Rear udder height

ETFA-Liver、TRIM27-Macrophage、PAPOLA-Monocytes

Rear teat placemen

ETFA-Liver、KHNYN-Intramuscular_fat、PKM-Macrophage

Rear legs rear view

SRPRA-Blood、ALPL-Blood

Net merit

C2CD2-Embryo、TRIM27-Macrophage

Metritis

EXOC4-Blood、CIDEB-Blood、LTB4R-Blood、ABCC6-Liver

Ketosis

FLT1-Macrophage、ATP8A2-Liver、LTB4R-Blood、DCAF11-Blood、RNF31-Milk_cell、FITM1-Blood、MRPL18-Blood

Hypocalcemia

ATP8A2-Liver

Front teat placement

ETFA-Liver、CIDEB-Blood

Fore udder attachment

ETFA-Liver、GSKIP-Muscle、ST3GAL4-Blood、DCPS-Liver

Feet and legs

SRPRA-Blood

Displaced abomasum

ATP8A2-Liver、EXOC4-Blood、HP1BP3-Lymph_node

Dairy form

TRIM27-Macrophage、ACAT2-Liver

Body depth

KIRREL3-Adipose、PRKAR1A-Blood

Foot angle

GTF3A-Embryo、SRPRA-Blood

Overall conformation score

ETFA-Liver、SRPRA-Blood、ST3GAL4-Blood