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Fig. 4 | BMC Genomics

Fig. 4

From: Identification of long noncoding RNAs in injury-resilient and injury-susceptible mouse retinal ganglion cells

Fig. 4

Fluorescent in situ hybridization validation of two lncRNAs upregulated in injured ooDSGCs. Retina sections 3 days post crush (injured) (a) and sham control (normal) (b), probed for Opn4 (green), Cartpt (red) and XLOC_020964 (white). Injured (c, e) and normal retina sections (d, f), probed for Cartpt (green; c, d) or Opn4 (green; e, f), Ecel1 (red) and RP23-416O18.4 (white). Ecel1 is the closest neighbor of the lincRNA RP23-416O18.4 and both are differentially upregulated in injured ooDSGCs. Quantification of the percentage of ooDSGCs (g) and ipRGCs (h) cells expressing the novel lncRNA XLOC_020964 in retina sections 3 days post crush and sham control. Values were normalized to the total of Cartpt+ or Opn4+ cells. (i) Quantification of the percentage of ooDSGCs cells co-expressing the lincRNA RP23-416O18.4 and Ecel1 in retina sections 3 days post crush and sham control. Values were normalized to the total of Cartpt+/Ecel1+ cells. * T-test, p < 0.05. Scale bar, 25 μm. Ganglion cell layer (GCL)

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BMC Genomics

ISSN: 1471-2164

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