Table 2 Candidate genes identified by integrated haplotype score (iHS) test under the evidence of signature of selection in the Brazilian Mangalarga Marchador horses

ENSECAG00000008623

1

149,907,955

150,022,286

SPRED1

sprouty related EVH1 domain containing 1

ENSECAG00000010114

1

149,706,774

149,775,059

RASGRP1

RAS guanyl releasing protein 1

ENSECAG00000005510

2

28,397,066

28,398,058

GPR3

G protein-coupled receptor 3

ENSECAG00000010268

2

28,323,886

28,385,023

WASF2

WAS protein family member 2

ENSECAG00000011296

2

28,562,401

28,609,929

SLC9A1

solute carrier family 9 member A1

ENSECAG00000014444

2

28,406,073

28,409,277

CD164L2

CD164 molecule like 2

ENSECAG00000014857

2

28,412,906

28,416,935

FCN3

ficolin 3

ENSECAG00000015410

2

28,420,416

28,429,784

MAP3K6

mitogen-activated protein kinase kinase kinase 6

ENSECAG00000020672

2

28,430,246

28,438,417

SYTL1

synaptotagmin like 1

ENSECAG00000023706

2

28,443,577

28,453,634

TMEM222

transmembrane protein 222

ENSECAG00000024411

2

28,463,993

28,508,594

WDTC1

WD and tetratricopeptide repeats 1

ENSECAG00000009649

3

7,693,420

7,744,860

LPCAT2

lysophosphatidylcholine acyltransferase 2

ENSECAG00000011520

3

7,794,621

7,835,751

SLC6A2

solute carrier family 6 member 2

ENSECAG00000009281

4

13,120,953

13,294,999

GLI3

GLI family zinc finger 3

ENSECAG00000007481

5

12,015,652

12,304,265

ASTN1

astrotactin 1

ENSECAG00000024570

5

12,310,453

12,412,709

BRINP2

BMP/retinoic acid inducible neural specific 2

ENSECAG00000025428

5

12,172,407

12,172,489

eca-mir-488

ENSECAG00000000386

6

34,369,455

34,374,801

LRRC23

leucine rich repeat containing 23

ENSECAG00000000465

6

34,410,281

34,420,057

PTPN6

protein tyrosine phosphatase, non-receptor type 6

ENSECAG00000000701

6

5,486,218

5,551,290

FN1

fibronectin 1

ENSECAG00000000726

6

70,865,117

70,867,507

HOXC9

homeobox C9

ENSECAG00000003682

6

70,892,992

70,894,488

HOXC6

homeobox C6

ENSECAG00000004151

6

70,897,601

70,899,132

HOXC5

homeobox C5

ENSECAG00000004202

6

70,917,898

70,919,290

HOXC4

homeobox C4

ENSECAG00000007386

6

34,377,361

34,383,187

ENO2

enolase 2

ENSECAG00000009049

6

34,274,460

34,301,295

CD4

CD4 molecule

ENSECAG00000009519

6

34,515,391

34,524,075

C1S

complement C1s

ENSECAG00000012522

6

34,321,532

34,326,725

GNB3

G protein subunit beta 3

ENSECAG00000014517

6

34,328,207

34,330,205

CDCA3

cell division cycle associated 3

ENSECAG00000014532

6

34,331,414

34,344,976

USP5

ubiquitin specific peptidase 5

ENSECAG00000014653

6

5,446,142

5,472,875

ATIC

5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase/IMP cyclohydrolase

ENSECAG00000015581

6

34,346,419

34,349,728

TPI1

triosephosphate isomerase 1

ENSECAG00000016937

6

34,425,844

34,429,448

PHB2

prohibitin 2

ENSECAG00000019250

6

34,304,988

34,308,833

GPR162

G protein-coupled receptor 162

ENSECAG00000021403

6

34,393,931

34,400,776

ATN1

atrophin 1

ENSECAG00000021815

6

34,310,310

34,319,714

P3H3

prolyl 3-hydroxylase 3

ENSECAG00000022412

6

34,429,726

34,434,811

EMG1

EMG1, N1-specific pseudouridine methyltransferase

ENSECAG00000023202

6

34,435,377

34,471,395

LPCAT3

lysophosphatidylcholine acyltransferase 3

ENSECAG00000024867

6

70,802,998

70,809,716

HOXC13

homeobox C13

ENSECAG00000024869

6

34,402,198

34,404,001

C6H12orf57

chromosome 6 C12orf57 homolog

ENSECAG00000024893

6

70,819,239

70,820,860

HOXC12

homeobox C12

ENSECAG00000024900

6

70,837,383

70,840,203

HOXC11

homeobox C11

ENSECAG00000024985

6

70,850,147

70,854,018

HOXC10

homeobox C10

ENSECAG00000025389

6

34,423,082

34,423,146

eca-mir-200c

ENSECAG00000025607

6

70,898,503

70,898,599

eca-mir-615

ENSECAG00000026310

6

34,423,490

34,423,561

eca-mir-141

ENSECAG00000027042

6

34,402,169

34,402,230

U7 small nuclear RNA

ENSECAG00000027594

6

34,426,452

34,426,715

small nucleolar RNA U89

ENSECAG00000003757

10

6,624,595

6,634,234

GAPDHS

glyceraldehyde-3-phosphate dehydrogenase, spermatogenic

ENSECAG00000005226

10

6,561,153

6,562,124

FFAR2

free fatty acid receptor 2

ENSECAG00000011198

10

60,335,470

60,340,309

AMD1

adenosylmethionine decarboxylase 1

ENSECAG00000011975

10

6,634,647

6,636,230

TMEM147

transmembrane protein 147

ENSECAG00000012822

10

9,635,035

9,645,344

EIF3K

eukaryotic translation initiation factor 3 subunit K

ENSECAG00000013121

10

6,639,494

6,652,250

ATP4A

ATPase H+/K+ transporting subunit alpha

ENSECAG00000014214

10

60,375,200

60,382,281

GTF3C6

general transcription factor IIIC subunit 6

ENSECAG00000015344

10

9,510,873

9,616,030

RYR1

ryanodine receptor 1

ENSECAG00000017061

10

9,616,257

9,633,779

MAP4K1

mitogen-activated protein kinase kinase kinase kinase 1

ENSECAG00000017121

10

60,395,300

60,425,982

RPF2

ribosome production factor 2 homolog

ENSECAG00000020313

10

60,557,764

60,601,940

SLC16A10

solute carrier family 16 member 10

ENSECAG00000021777

10

9,692,742

9,718,476

ACTN4

actinin alpha 4

ENSECAG00000025001

10

6,589,049

6,591,925

KRTDAP

keratinocyte differentiation associated protein

ENSECAG00000006771

11

13,417,359

13,812,648

PRKCA

protein kinase C alpha

ENSECAG00000007214

11

13,765,651

14,005,312

CACNG4

calcium voltage-gated channel auxiliary subunit gamma 4

ENSECAG00000000176

13

1,935,848

1,947,933

ZDHHC4

zinc finger DHHC-type containing 4

ENSECAG00000008056

13

2,414,177

2,422,727

FSCN1

fascin actin-bundling protein 1

ENSECAG00000009724

13

2,153,427

2,160,374

RBAK

RB associated KRAB zinc finger

ENSECAG00000010225

13

1,882,012

1,913,837

GRID2IP

Grid2 interacting protein

ENSECAG00000011713

13

1,949,573

1,958,047

C7orf26

chromosome 7 open reading frame 26

ENSECAG00000013171

13

2,265,413

2,398,956

RNF216

ring finger protein 216

ENSECAG00000015935

13

2,463,585

2,465,463

ACTB

Equus caballus actin beta (ACTB), mRNA

ENSECAG00000016420

13

2,086,916

2,092,792

ZNF12

zinc finger protein 12

ENSECAG00000018678

13

2,472,540

2,510,292

FBXL18

F-box and leucine rich repeat protein 18

ENSECAG00000022114

13

2,711,477

2,738,292

WIPI2

WD repeat domain, phosphoinositide interacting 2

ENSECAG00000013897

16

65,160,454

65,270,909

RFTN1

raftlin, lipid raft linker 1

ENSECAG00000008768

18

79,106,315

80,034,010

PARD3B

par-3 family cell polarity regulator beta

ENSECAG00000012151

18

12,086,034

12,116,622

MARCO

macrophage receptor with collagenous structure

ENSECAG00000016824

18

80,076,435

80,186,347

NRP2

neuropilin 2

ENSECAG00000018298

18

76,437,419

76,456,956

STRADB

STE20-related kinase adaptor beta

ENSECAG00000019645

18

76,634,162

76,650,235

TMEM237

transmembrane protein 237

ENSECAG00000022800

18

76,653,422

76,689,588

MPP4

membrane palmitoylated protein 4

ENSECAG00000010916

20

50,162,197

50,233,536

TRAM2

translocation associated membrane protein 2

ENSECAG00000015579

20

50,310,519

50,323,621

TMEM14A

transmembrane protein 14A

ENSECAG00000016221

20

50,347,190

50,357,534

GSTA1

Equus caballus glutathione S-transferase alpha 1 (GSTA1), mRNA

ENSECAG00000019567

20

50,425,513

50,435,370

LOC100271875

glutathionine S-transferase alpha 3

ENSECAG00000004463

23

50,231,564

50,255,138

UBAP1

ubiquitin associated protein 1

ENSECAG00000004776

23

50,338,512

50,340,656

MYORG

myogenesis regulating glycosidase (putative)

ENSECAG00000004839

23

50,465,243

50,465,473

ENHO

Equus caballus energy homeostasis associated (ENHO), mRNA

ENSECAG00000006176

23

50,484,877

50,502,709

CNTFR

ciliary neurotrophic factor receptor

ENSECAG00000010758

23

50,257,759

50,299,304

KIF24

kinesin family member 24

ENSECAG00000011552

23

50,328,495

50,331,173

NUDT2

nudix hydrolase 2

ENSECAG00000011566

23

50,345,688

50,359,034

C9orf24

chromosome 9 open reading frame 24

ENSECAG00000012578

23

50,362,111

50,367,137

FAM219A

family with sequence similarity 219 member A

ENSECAG00000016961

23

50,426,532

50,464,571

DNAI1

dynein axonemal intermediate chain 1

ENSECAG00000027205

23

50,423,793

50,424,056

RNA, 7SK small nuclear pseudogene 24

ENSECAG00000002357

23

50,540,041

50,540,532

RPP25L

ribonuclease P/MRP subunit p25 like

ENSECAG00000013178

23

50,543,087

50,549,476

DCTN3

dynactin subunit 3

ENSECAG00000019783

23

50,562,602

50,564,385

SIGMAR1

sigma non-opioid intracellular receptor 1

ENSECAG00000001054

25

27,004,948

27,005,868

LOC100071212

olfactory receptor 1 L6-like

ENSECAG00000001330

25

27,025,906

27,026,868

OR5C1

olfactory receptor 5C1

ENSECAG00000002169

25

27,033,670

27,034,620

OR1K1

olfactory receptor family 1 subfamily K member 1

ENSECAG00000002222

25

27,136,728

27,138,002

ZBTB6

zinc finger and BTB domain containing 6

ENSECAG00000006897

25

26,957,307

26,958,330

LOC100071227

olfactory receptor 1 L4-like

ENSECAG00000006946

25

26,979,321

26,980,244

LOC100071218

olfactory receptor 1 L4-like

ENSECAG00000017397

25

27,143,414

27,153,522

ZBTB26

zinc finger and BTB domain containing 26

ENSECAG00000017729

25

27,161,291

27,312,547

RABGAP1

RAB GTPase activating protein 1

ENSECAG00000021253

25

26,896,324

27,056,065

PDCL

phosducin like

ENSECAG00000022176

25

27,085,189

27,132,323

RC3H2

ring finger and CCCH-type domains 2

ENSECAG00000025393

25

27,106,545

27,106,655

small nucleolar RNA SNORD90

ENSECAG00000007192

30

26,241,146

26,299,185

PTPRC

protein tyrosine phosphatase, receptor type C

ENSECAG00000023881

30

26,077,245

26,096,063

ATP6V1G3

ATPase H+ transporting V1 subunit G3

ENSECAG00000025552

30

26,398,918

26,399,027

eca-mir-181a-2