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Fig. 2 | BMC Genomics

Fig. 2

From: Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen

Fig. 2

Significantly differentially enriched immunological and cell signalling pathways in mice associated with transgene-encoded antigen expression from an adenovirus vector. Pathway over-representation analysis was performed on differentially expressed genes induced 24 h post-immunisation with a human adenovirus serotype 5 (HuAd5) encoding a bacterial (factor H binding protein, Ad-fHbp) or viral (pre-fusion F protein, Ad-preF), relative to HuAd5 encoding no antigen (Ad-empty). The enrichment of genes induced by Ad-fHbp pertaining to pathways categorised in the publicly available (a) integrating network objects with hierarchies (INOH) cell signalling pathway and (b) Reactome immunological pathway databases was assessed. c Immunological pathway enrichment was also assessed for Ad-preF. The x-axes correspond to the negative log10 pathway p-value associated with each pathway (y-axes). The dashed red lines correspond to a negative log10 pathway p-value cut-off of 0.05

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