Fig. 2From: Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigenSignificantly differentially enriched immunological and cell signalling pathways in mice associated with transgene-encoded antigen expression from an adenovirus vector. Pathway over-representation analysis was performed on differentially expressed genes induced 24 h post-immunisation with a human adenovirus serotype 5 (HuAd5) encoding a bacterial (factor H binding protein, Ad-fHbp) or viral (pre-fusion F protein, Ad-preF), relative to HuAd5 encoding no antigen (Ad-empty). The enrichment of genes induced by Ad-fHbp pertaining to pathways categorised in the publicly available (a) integrating network objects with hierarchies (INOH) cell signalling pathway and (b) Reactome immunological pathway databases was assessed. c Immunological pathway enrichment was also assessed for Ad-preF. The x-axes correspond to the negative log10 pathway p-value associated with each pathway (y-axes). The dashed red lines correspond to a negative log10 pathway p-value cut-off of 0.05Back to article page