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Fig. 3 | BMC Genomics

Fig. 3

From: Distinct patterns of whole blood transcriptional responses are induced in mice following immunisation with adenoviral and poxviral vector vaccines encoding the same antigen

Fig. 3

Transgene-encoded antigen-specific gene ontologies differ significantly between a bacterial and viral transgene product expressed from the same adenovirus vector. Gene expression profiles defined in mice 24 h after immunisation with a human adenovirus serotype 5 vector encoding either a bacterial (factor H binding protein, Ad-fHbp) or viral (pre-fusion F protein, Ad-preF) antigen were contrasted against each other to determine significantly differentially expressed genes (DEGs). Gene ontology (GO) over-representation analysis was performed on these DEGs to determine significantly differentially enriched GOs. The colour and position of circles along the x-axis corresponds to the negative log10 p-value associated with a given gene ontology (y-axis), while the size of the circle corresponds to the number of genes defined for that ontology. The horizontal grey line indicates the threshold for significant (pathway p-value < 0.05)

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