Table 1 Clinical Characteristics of Mongolia and Thailand Cohorts IQR: Interquartile range; HBV: Hepatitis B virus; HCV: Hepatitis C virus; HDV: Hepatitis D virus. AFP: alpha-fetoprotein level. AAV2/13 refers to any sequence that most closely resembles the full AAV2 genome or the partial AAV13 genome but could be phylogenetically in between. Missing data excluded. Entries with a – were not measured

N or mean

%

N or mean

%

N or mean

%

Age (median, IQR)

60

55–66

56.3

51–61

59.5

54–65

BMI (median, IQR)

24.7

21.3–27.9

22.8

20.8–25.3

22.3

19.8–24.4

Smoker

19/62

30.6 %

30/45

66.7 %

55/100

55 %

Drink Alcohol

8/62

12.9 %

37/47

78.7 %

64/100

64 %

HBV (HBsAg)

48/70

68.6 %

22/42

52.4 %

2/84

2.4 %

HCV (HCAb)

40/70

57.1 %

5/40

12.5 %

3/83

3.6 %

HDV (HDAb)

27/70

38.6 %

-

-

-

-

Fam History Liver Cancer

11/61

18.0 %

18/59

30.5 %

41/94

43.6 %

Cirrhosis

27/56

48.2 %

23/36

63.8 %

-

-

AFP (median, IQR)

-

-

38.6

5.8-320.7

-

-

Multinodular

13/61

21.3 %

12/36

33.3 %

3/42

7.1 %

TNM staging

Stage I

1

1.9 %

13

36.1 %

16

40 %

Stage II

19

35.8 %

15

41.7 %

5

12.5 %

Stage III

31

58.5 %

5

13.9 %

7

17.5 %

Stage IV

2

3.8 %

3

8.3 %

12

30 %

AAV2/13 + Tumor RNA-Seq

0

0 %

0

0 %

0

0 %

AAV2/13 + Non-tumor RNA-Seq

2

2.9 %

3

6.4 %

14

14 %

AAV2/13 + Tumor Viral Capture DNA-Seq

0

0 %

1

33.3 %

4

4 %

AAV2/13 + Non-tumor Viral Capture DNA-Seq

0

0 %

3

6.4 %

13

13 %

AAV2/13 + Tumor Genome Insertion

0

0 %

1

2.1 %

2

2 %

AAV2/13 + Non-tumor Genome Insertion

0

0 %

2

4.3 %

9

9 %

AAV2/13 + Shared Genome Insertion

0

0 %

1

2.1 %

0

0 %