Fig. 1

Most appropriate tissue of analysis to inquire for cardiac arrhythmias. A. Correlation analysis based on genes with median TPM > 1.5 between the TI (heart) and all easily accessible TAs. The highest correlation coefficient between TI and TAs was obtained by skeletal muscle (correlation coefficients marked in the purple rectangular: r = 0.43 for the heart left ventricle and r = 0.48 heart atrial appendage). B. Venn diagrams showing the number of expressed genes (median TPM > 1.5) in TI (heart) and different TAs. Skin and skeletal muscle express most of the genes included in the “Cardiac Arrhythmia” list. When all TAs are considered, 30 of the 39 genes annotated in the “Cardiac arrhythmia” list (PI = phenotype of interest) are captured and only 9 genes are not covered in any of the TAs. C. Venn diagrams showing the number of transcripts (median TPM > 1.5) in TI (heart) and different TAs. Using the “Cardiac Arrhythmia” list, skin and skeletal muscle show the highest number of overlapping transcripts with heart. D. Violin plot of genes with low cardiac expression (median TPM < 1.5). Numbers above violins represent standard deviation. The only gene with low expression and low variability is KCND2