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Fig. 3 | BMC Genomics

Fig. 3

From: CoRe: a robustly benchmarked R package for identifying core-fitness genes in genome-wide pooled CRISPR-Cas9 screens

Fig. 3

Fitness effects of CFG sets across cell lines. A. Median percentage of cell lines in which the genes in the predicted sets or core-fitness gene (CFG) or common-essential gene (CEG) sets are significantly essential. B. Threshold of minimal number of dependent cell lines n required by the baseline daisy model predictor (DM) to attain the true positive rates (TPRs) observed across tested methods. C. Ratios between median numbers of dependent cell lines for predicted sets divided by the threshold n of the DM to attain their TPRs. D. Median fitness effect exerted by the genes in the predicted CFG/CEG sets. E. Ratio between the median fitness effect in D and the median fitness effect exerted by the DM at the observed TPRs. F. Ratio between the number of genes in the predicted sets and those predicted by the DM at the observed TPRs

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BMC Genomics

ISSN: 1471-2164

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