Fig. 7
From: Identification and functional analysis of novel oncogene DDX60L in pancreatic ductal adenocarcinoma
Knockdown of DDX60L and MYEOV inhibited the expression of CXCL2 and led to good prognosis in PDAC. (A) Expression of CXCL2 in siDDX60L- and siMYEOV-transfected MiaPaCa2 and PANC-1 cells. Two-way ANOVA is used to analyze significant differences in the gene expression levels between control cancer cells and siRNA treated cancer cells. ****p < 0.0001. (B) The Kaplan–Meier Plotter analysis showed that patients from the TCGA-PDAC dataset (n = 177) [11] who expressed high levels of CXCL2 had a poor prognosis. (C-D) The Kaplan–Meier Plotter analysis showed that PDAC patients with low CXCL2 and DDX60L expression in tumors (C) and those with low CXCL2 and MYEOV expression in tumors (D) had a significantly improved overall survival. The p-values are shown. CXCL2, C-X-C motif chemokine ligand 1; DDX60L, DExD/H-box 60 like; MYEOV, myeloma overexpressed; OS, overall survival; PDAC, pancreatic ductal adenocarcinoma; TCGA, The Cancer Genome Atlas