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Table 4 First-line and second-line drug-related SNPs identified using TBProfiler and TTD database search result of the drug functional annotations [24]

From: The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia

Drug Gene SNP mutation Protein Target TTD Link
First-line
 Rifampicin rpoB S450L, D435Y, H445Y, L430P, Q432K Bacterial RNA polymerase switch region (Bact RNAP-SR) http://db.idrblab.net/ttd/data/drug/details/d0g3dl
 Isoniazid katG S315T Bacterial Fatty acid synthetase I (Bact inhA) http://db.idrblab.net/ttd/data/target/details/t79068
 Isoniazid kasA G312S
 Isoniazid inhA I21V
 Isoniazid Rv1482c-fabG1 C-15 T
 Streptomycin rpsL K43R Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) http://db.idrblab.net/ttd/data/target/details/t72657
 Streptomycin rrs A514C, A514T Mycobacterium Arabinosyltransferase C (MycB embC) http://db.idrblab.net/ttd/data/target/details/t30578
 Ethambutol embB M306L, M306V, D1024N Mycobacterium Arabinosyltransferase C (MycB embC) http://db.idrblab.net/ttd/data/target/details/t30578
 Pyrazinamide pncA W119R Bacterial Fatty acid synthetase I (Bact inhA) http://db.idrblab.net/ttd/data/target/details/t79068
Second-Line
 Amikacin rrs A514C Staphylococcus 30S ribosomal subunit (Stap-coc pbp2) http://db.idrblab.net/ttd/data/target/details/t72657