The whole-genome sequencing in predicting Mycobacterium tuberculosis drug susceptibility and resistance in Papua, Indonesia

Table 4 First-line and second-line drug-related SNPs identified using TBProfiler and TTD database search result of the drug functional annotations [24]

Drug	Gene	SNP mutation	Protein Target	TTD Link
First-line
Rifampicin	rpoB	S450L, D435Y, H445Y, L430P, Q432K	Bacterial RNA polymerase switch region (Bact RNAP-SR)	http://db.idrblab.net/ttd/data/drug/details/d0g3dl
Isoniazid	katG	S315T	Bacterial Fatty acid synthetase I (Bact inhA)	http://db.idrblab.net/ttd/data/target/details/t79068
Isoniazid	kasA	G312S
Isoniazid	inhA	I21V
Isoniazid	Rv1482c-fabG1	C-15 T
Streptomycin	rpsL	K43R	Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	http://db.idrblab.net/ttd/data/target/details/t72657
Streptomycin	rrs	A514C, A514T	Mycobacterium Arabinosyltransferase C (MycB embC)	http://db.idrblab.net/ttd/data/target/details/t30578
Ethambutol	embB	M306L, M306V, D1024N	Mycobacterium Arabinosyltransferase C (MycB embC)	http://db.idrblab.net/ttd/data/target/details/t30578
Pyrazinamide	pncA	W119R	Bacterial Fatty acid synthetase I (Bact inhA)	http://db.idrblab.net/ttd/data/target/details/t79068
Second-Line
Amikacin	rrs	A514C	Staphylococcus 30S ribosomal subunit (Stap-coc pbp2)	http://db.idrblab.net/ttd/data/target/details/t72657

ISSN: 1471-2164