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Fig. 1 | BMC Genomics

Fig. 1

From: Urinary peptidomics reveals proteases involved in idiopathic membranous nephropathy

Fig. 1

Workflow of the study. First, urine samples were collected from subjects; next, peptides were extracted from the samples and analyzed with liquid chromatography-tandem mass spectrometry (LC-MS/MS). Peptides differentially expressed in patients with idiopathic membranous nephropathy (IMN) and matched proteins were identified. Bioinformatics analyses were performed to predict kidney-originated proteins and reveal the expression pattern in kidneys based on the iProX database. Functional enrichment analysis was conducted using the Proteasix database to predict proteases. Finally, proteases were validated via Gene Expression Omnibus (GEO) database and western blot analyses. HC, healthy control; OD, other kidney disease

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