Table 3 The KEGG pathways enriched in the comparison

ABCA3

ABC transporters

ko02010

ABCC1

Sphingolipid signaling pathway; Vitamin digestion and absorption; ABC transporters

ko04071; ko04977; ko02010

ABL2

ErbB signaling pathway; Ras signaling pathway;

ko04012; ko04014;

ACACA

Aflatoxin biosynthesis; AMPK signaling pathway; Fatty acid biosynthesis; Fatty acid metabolism; Glucagon signaling pathway; Insulin signaling pathway; Propanoate metabolism; Pyruvate metabolism;

ko00254; ko04152; ko00061; ko01212; ko04922; ko04910; ko00640; ko00620

ADIPOQ

Adipocytokine signaling pathway; AMPK signaling pathway; Longevity regulating pathway – mammal; PPAR signaling pathway;

ko04920; ko04152; ko04211; ko03320;

ADRA2B

cGMP - PKG signaling pathway; Neuroactive ligand-receptor interaction;

ko04022; ko04080;

ANKS1B

Aldosterone synthesis and secretion;

ko04925;

ANO2

Olfactory transduction;

ko04740;

AP1S2

Lysosome;

ko04142;

ARHGEF11

Vascular smooth muscle contraction

ko04270

ARHGEF12

Axon guidance; Platelet activation; Regulation of actin cytoskeleton; Vascular smooth muscle contraction;

ko04360; ko04611; ko04810; ko04270

ARRB1

Chemokine signaling pathway; Endocytosis; Hedgehog signaling pathway; MAPK signaling pathway; Olfactory transduction;

ko04062; ko04144; ko04340; ko04010; ko04740;

ATG7

Autophagy – animal; Autophagy - other eukaryotes; Autophagy – yeast; Ferroptosis;

ko04140; ko04136; ko04138; ko04216

ATP2A3

Calcium signaling pathway; cGMP - PKG signaling pathway; Pancreatic secretion;

ko04020; ko04022; ko04972;

BCL2L13

Mitophagy – animal;

ko04137;

BMP4

Hedgehog signaling pathway – fly; Hippo signaling pathway; MAPK signaling pathway – fly; Signaling pathways regulating pluripotency of stem cells; TGF-beta signaling pathway; Thyroid hormone signaling pathway;

ko04341; ko04390; ko04013; ko04550; ko04350; ko04919;

CA12

Nitrogen metabolism;

ko00910;

CAMK2G

Adrenergic signaling in cardiomyocytes; Axon guidance; Calcium signaling pathway; Cholinergic synapse; Circadian entrainment; Dopaminergic synapse; ErbB signaling pathway; Gastric acid secretion; Glucagon signaling pathway; GnRH signaling pathway; HIF-1 signaling pathway; Inflammatory mediator regulation of TRP channels; Insulin secretion; Long-term potentiation; Melanogenesis; Necroptosis; Neurotrophin signaling pathway; Olfactory transduction; Oocyte meiosis; Oxytocin signaling pathway; Phototransduction – fly; Wnt signaling pathway

ko04261; ko04360; ko04020; ko04725; ko04713; ko04728; ko04012; ko04971; ko04922; ko04912; ko04066; ko04750; ko04911; ko04720; ko04916; ko04217; ko04722; ko04740; ko04114; ko04921; ko04745; ko04310

CAMKK2

Adipocytokine signaling pathway; AMPK signaling pathway; Autophagy – animal; Longevity regulating pathway – mammal; Oxytocin signaling pathway;

ko04920; ko04152; ko04140; ko04211; ko04921;

CD19

B cell receptor signaling pathway; Hematopoietic cell lineage; PI3K-Akt signaling pathway;

ko04662; ko04640; ko04151;

CLIP1

mTOR signaling pathway;

ko04150;

CR2

B cell receptor signaling pathway; Complement and coagulation cascades; Hematopoietic cell lineage;

ko04662; ko04610; ko04640;

CXCR5

Chemokine signaling pathway; Cytokine-cytokine receptor interaction;

ko04062; ko04060;

DLG3

Hippo signaling pathway; Tight junction;

ko04390; ko04530;

DNMT3A

Cysteine and methionine metabolism;

ko00270;

EXOC7

Insulin signaling pathway;

ko04910;

FAAH

Retrograde endocannabinoid signaling;

ko04723;

FARS2

Aminoacyl-tRNA biosynthesis

ko00970;

FLNB

Focal adhesion; MAPK signaling pathway;

ko04510; ko04010;

GAB2

Fc epsilon RI signaling pathway; Fc gamma R-mediated phagocytosis; Osteoclast differentiation; Phospholipase D signaling pathway; Ras signaling pathway; Sphingolipid signaling pathway;

ko04664; ko04666; ko04380; ko04072; ko04014; ko04071;

GBGT1

Glycosphingolipid biosynthesis - globo and isoglobo series;

ko00603;

GTF2IRD1

Basal transcription factors; cGMP - PKG signaling pathway;

ko03022; ko04022;

ITGA7

ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway; Regulation of actin cytoskeleton;

ko04512; ko04510; ko04151; ko04810;

KCNMA1

cGMP - PKG signaling pathway; Insulin secretion; Pancreatic secretion; Renin secretion; Salivary secretion; Vascular smooth muscle contraction

ko04022; ko04911; ko04972; ko04924; ko04970; ko04270

LPCAT1

Ether lipid metabolism; Glycerophospholipid metabolism;

ko00565; ko00564;

MAP 34-B

NOD-like receptor signaling pathway; Salivary secretion;

ko04621; ko04970;

MAP 4

MAPK signaling pathway;

ko04010;

MAT2B

Biosynthesis of amino acids; Cysteine and methionine metabolism;

ko01230; ko00270;

MS4A1

Hematopoietic cell lineage;

ko04640;

MTMR3

Autophagy – animal; Inositol phosphate metabolism; Phosphatidylinositol signaling system;

ko04140; ko00562; ko04070;

NCOR2

Notch signaling pathway;

ko04330;

PARS2

Aminoacyl-tRNA biosynthesis

ko00970;

PARD3

Axon guidance; Chemokine signaling pathway; Endocytosis; Hippo signaling pathway; Hippo signaling pathway -fly; Neuroactive ligand-receptor interaction; Rap1 signaling pathway; Tight junction;

ko04360; ko04062; ko04144; ko04390; ko04391; ko04080; ko04015; ko04530

PKMYT1

Cell cycle; Oocyte meiosis; Progesterone-mediated oocyte maturation;

ko04110; ko04114; ko04914;

PGS1

Glycerophospholipid metabolism;

ko00564;

PIAS2

Jak-STAT signaling pathway; Ubiquitin mediated proteolysis;

ko04630; ko04120;

PSAP

Lysosome;

ko04142;

PXN

Chemokine signaling pathway; Focal adhesion; Leukocyte transendothelial migration; Regulation of actin cytoskeleton; VEGF signaling pathway;

ko04062; ko04510; ko04670; ko04810; ko04370

RPS24

Ribosome;

ko03010;

SMURF1

Adherens junction; Axon guidance; cAMP signaling pathway; Endocytosis; Hedgehog signaling pathway; Hedgehog signaling pathway – fly; TGF-beta signaling pathway; Ubiquitin mediated proteolysis

ko04520; ko04360; ko04024; ko04144; ko04340; ko04341; ko04350; ko04120

ST3GAL3

Glycosaminoglycan biosynthesis - keratan sulfate; Glycosphingolipid biosynthesis - lacto and neolacto series; Mannose type O-glycan biosynthesis; Other types of O-glycan biosynthesis; Various types of N-glycan biosynthesis;

ko00533; ko00601; ko00515; ko00514; ko00513;

SYNGAP1

Ras signaling pathway;

ko04014;

SYVN1

Protein processing in endoplasmic reticulum; Ubiquitin mediated proteolysis;

ko04141; ko04120;

TCF7L2

Adherens junction; Hippo signaling pathway; Melanogenesis; Wnt signaling pathway

ko04520; ko04390; ko04916; ko04310

TFDP2

Cell cycle;

ko04110;

THOC5

RNA transport;

ko03013;

TJP3

Tight junction

ko04530

TNFRSF13B

Cytokine-cytokine receptor interaction; Intestinal immune network for IgA production;

ko04060; ko04672;

TNXB

ECM-receptor interaction; Focal adhesion; PI3K-Akt signaling pathway;

ko04512; ko04510; ko04151;

ULK1

Autophagy – animal; Autophagy - other eukaryotes; Autophagy – yeast; Longevity regulating pathway – worm; Mitophagy – yeast; mTOR signaling pathway;

ko04140; ko04136; ko04138; ko04212; ko04139; ko04150;

USP2

IL-17 signaling pathway;

ko04657;

WNT4

Hippo signaling pathway; Melanogenesis; mTOR signaling pathway; Signaling pathways regulating pluripotency of stem cells; Thyroid hormone signaling pathway; Wnt signaling pathway;

ko04390; ko04916; ko04150; ko04550; ko04919; ko04310;