Table 5 Total 14 functional groups have different behaviors in different contexts
Functional group | Contained genes | OCU | OCD |
|---|---|---|---|
1. Autoregulatory - up | CCL9, CCR1, CD109, CXCL10, SDC1, VEGFC | Activation | Inhibition |
2. Cell Differentiation signaling factors - down | PLCB4, PLCB2, GIT1, DOCK5, TRAF1, TRAF6 | Activation | Inhibition |
3. Cell Differentiation | CLCN7, CAR2, CALCR, CSF1R, TREM2, TNFRSF11A, OSCAR, OCSTAMP, MST1R, ITGB3, DCSTAMP | Activation | Inhibition |
4. Cytoskeleton Control | DCSTAMP, LAD1, MYO1B, OCSTAMP, SCIN, MYOD1, MARCKS | Activation | Inhibition |
5. Integrin Beta3 | CLCN7, OCSTAMP, CALCR, MST1R, CTSK, MMP14, ITGB3, MYO1D, ACP5, MMP9, CAR2, OSCAR | Activation | Inhibition |
6. Secreted Factors for External Cells - up | INF2, SEMA4D, SGPL1, SPP1, CXCL10, CCL9 | Activation | Inhibition |
7. Coupling Factors | PGF,SPNS2,CD200,SGPL1,SEMA7A,LIF,CST7 | Activation | Inhibition |
8. ACID & Enzymes for Matrix Dissolution | VCAN, ATP6V0D2, CAR2, CLCN7, SLC9B6, CTSK, ACP5, PDE2A, MMP14, HTRA1, MMP9, ADAM10, ATP6V0B, ATP6V0C, ATP6V0C-PS2 | Activation | Inhibition |
9. Autoregulatory - down | C1QA, C1QB, C1QC, CCL2, CCL3, CCL4, CCL6, CCL7, CXCL14, IGFBP4, PF4 | Inhibition | Activation |
10. Calcinuren Pathway | CALM1, CAMK1, CAMK2A, CALM2, CALM3, PPP3CA | Inhibition | Activation |
11. Cell Differentiation signaling factors - up | PPP2R3A, PPP3CA, CALM2, PPP2R3C, CAMK1, TNFAIP2, CAMK2A, CALM3, CALM1 | Inhibition | Activation |
12. Cell Signaling | SLIT1, SGPL1, INFB, IL10, CXCL5, IGF1, SPP1, SLIT3, C1QA, CCL8, CCL7, C1QC, C1QB | Inhibition | Activation |
13. MSC Signature | ACTA2, ACTG2, BGN, CCND1, COL1A1, COL1A2, COL2A1, DKK3, FN1, SERPINH1, SPARC, TNC | Inhibition | Activation |
14. Secreted Factors for External Cells - down | CCL6, CCL4, CCL3, CCL2, C1QC, C1QB, CCL7, CXCL14, CD200R1, CXCL16, IGF1, APOE, C1QA | Inhibition | Activation |