Fig. 6

Six genomic features of ASP/L-related genes independently regulate organism complexity. (A) Intersection of significant KEGG Orthologs (KOs) among six genomic features. Spearman’s correlation and phylogenetic general least squares (PGLS) regression were calculated between these genomic features and organism complexity for each KO in the FirstSpeciesSet of 14 species. Significant KOs were defined as having Spearman’s ρ > 0.4 and PGLS P < 0.05. (B) Principal component analysis of the six genomic features based on the Spearman’s ρ for 219 KOs. The data points represent KOs and the shapes represent the four KEGG pathways. (C) Summary of the correlations among ASP/L, the six genomic features of ASP/L-related proteins, and organism complexity