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Fig. 1 | BMC Genomics

Fig. 1

From: Holstein Friesian dairy cattle edited for diluted coat color as a potential adaptation to climate change

Fig. 1

Schematic overview of the PMEL target region. Shown is the DNA sequence for the relevant region of the PMEL gene with the binding site for editor 129_F (bold, underlined), PAM sequence (grey highlight) and the location of the three bp deletion (box). Below is the aligned sequence of the ss HDR template (ssODN) specifying a three bp deletion (dashes). The corresponding amino acid sequence for PMEL is given in single letter code above the DNA sequence with lower case indicating amino acids of the predicted signal peptide according to the UniProt annotation for bovine PMEL (entry Q06154)

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