Fig. 2

Global changes in gene expression upon mbk-1 loss in wildtype and long-lived C. elegans. a and b Differential gene expression between mbk-1(−) and mbk-1(+) worms in the backgrounds indicated, visualized in MA-plots (a) and Volcano plots (b). Light blue lines indicate |Log₂FC| > 0.58 and p_adj < 0.05, open triangles indicate data points beyond axis limits. c and d Overlap of mbk-1 induced (c) and mbk-1 repressed genes (d) from the backgrounds indicated visualized by Venn-diagrams. See Table S4 for statistical analysis. e and f Biological processes enriched (q < 0.05) among mbk-1 induced (e) and mbk–1 repressed genes (f) in the backgrounds indicated. See Table S6 for complete analysis