Fig. 2

Co-expression network illustration of lncRNA-mRNA and functional analysis of target mRNAs in CPAM-I lung tissues. a. Scatter plot shows DE-lncRNAs of CPAM-I compared with control samples and the number of co-expressed DE mRNAs. Up and down-regulated lncRNAs are respectively labeled in red and blue points. Cutoffs of p-value < 0.01 and Pearson coefficient > 0.6 were applied to identify the co-expression pairs. b. Top 10 most enriched GO terms (biological process) by DE mRNAs co-expressed with DE-lncRNAs of CPAM-I lung tissues compared with control samples. c. The top 10 enriched KEGG pathways by DE mRNAs co-expressed with DE-lncRNAs of CPAM-I lung tissues compared with control samples. d. The co-expression network between the lncRNAs detected in the CPAM-I lung tissues and the co-expressed mRNAs involved in the four GO terms. lncRNA are plotted with yellow circles, co-expression mRNAs are plotted with light blue circles, mRNA-enriched GO terms are plotted with red circles. e. The expression level of the six lncRNAs in CPAM-I lung tissues