Fig. 4

Expanded model summarizing major facets of regenerative growth signaling in boa constrictors after feeding. a Pathway overlap of all significantly activated or inhibited canonical pathways from the time series. b Close-up view of relationships between major pathways hypothesized to integrate signals from stress response and growth. c Summary of early signaling events hypothesized to regulate the early stages of regeneration post-feeding. Molecules and pathways in orange are activated, and in blue are suppressed. Arrowhead ends indicate activation by, and circle ends indicate inhibition by (e.g., PTEN signaling inhibits PI3K/AKT, but PTEN signaling is suppressed, allowing activation of PI3K/AKT). Unless otherwise stated, molecule and pathway activation states and interactions hypothesized are primarily supported by IPA. Activation hypothesized from phosphoproteomic data is indicated by an asterisk (*). Interactions hypothesized from literature are cited