Fig. 11

Distributions of CpG 5mC surrounding the transcriptional start site (TSS; ± 2.0 kb) to ONC differed markedly from that of 5hmC. A, Although less pronounced than in tadpole SCI, the density of CpG DMRs across the TSS follows the same pattern as for tadpole SCI, with CpG 5mC DMRs increasing for the top two quartiles of RNA expression with injury. Units and labels are as in Fig. 4. B, In contrast, 5hmC showed no such response, and overall was markedly different from the pattern of CpG 5mC (see text for details). Units and labels are as in Fig. 7