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Fig. 7 | BMC Genomics

Fig. 7

From: Developmental and Injury-induced Changes in DNA Methylation in Regenerative versus Non-regenerative Regions of the Vertebrate Central Nervous System

Fig. 7

Heatmaps of active histone marks (H3K4me3 and H3K27ac) across the TSS, relative to quartiles of RNA expression (A) and Promoter CpG-DMR’s (B) in regenerative CNS tissues after SCI (left) and ONC (right). A, the presence of active marks declined with decreasing levels of RNA expression (Q1 to Q4, most to least). B, active histone marks were more highly represented among DMRs exhibiting increased methylation with injury (DMR Up) than among those exhibiting decreased methylation (DMR DN). See Fig. 5 for total numbers of DMR-bearing genes in each category. x-axis units as in Fig. 4; y-axis units, number of mapped reads in a 50 bp bin x 1 million/total number of mapped reads

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