Table 4 Analysis of IL1B (rs1143634) × IL1RN (rs2234677) interaction in relation to BMI (dominant model). OR—odds ratio; CI—confidence interval, NA – not applicable
From: The interactions between interleukin-1 family genes: IL1A, IL1B, IL1RN, and obesity parameters
IL1RN (rs2234677) | |||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Dominant model | |||||||||||||||||
G/G | A/G-A/A | ||||||||||||||||
IL1B(rs1143634) | OVERBMI | CONBMI | OR | 95% CI | OVERBMI | CONBMI | OR | 95% CI | p | ||||||||
C/C | 10 | 15 | 1.00 | NA | NA | 7 | 20 | 0.52 | 0.16 | 1.70 | 0.02 | ||||||
T/C | 1 | 24 | 0.06 | 0.01 | 0.54 | 6 | 13 | 0.69 | 0.20 | 2.43 | |||||||
T/T | 0 | 1 | 0.00 | 0.00 | NA | 1 | 3 | 0.50 | 0.05 | 5.51 | |||||||
Codominant model | |||||||||||||||||
G/G | A/G | A/A | |||||||||||||||
OVERBMI | CONBMI | OR | 95% CI | OVERBMI | CONBMI | OR | 95% CI | OVERBMI | CONBMI | OR | 95% CI | p | |||||
C/C | 10 | 15 | 1.00 | NA | NA | 6 | 17 | 0.53 | 0.16 | 1.81 | 1 | 3 | 0.5 | 0.05 | 5.51 | 0.03 | |
T/C | 1 | 24 | 0.06 | 0.01 | 0.54 | 4 | 12 | 0.50 | 0.13 | 2.00 | 2 | 1 | 3.0 | 0.24 | 37.67 | ||
T/T | 0 | 1 | 0.00 | 0.00 | NA | 1 | 3 | 0.50 | 0.05 | 5.51 | 0 | 0 | NA | NA | NA | ||
Recessive model | |||||||||||||||||
G/G-A/G | A/A | ||||||||||||||||
OVERBMI | CONBMI | OR | 95% CI | OVERBMI | CONBMI | OR | 95% CI | p | |||||||||
C/C | 16 | 32 | 1.00 | NA | NA | 1 | 3 | 0.67 | 0.06 | 6.93 | 0.07 | ||||||
T/C | 5 | 36 | 0.28 | 0.09 | 0.84 | 2 | 1 | 4.00 | 0.34 | 47.50 | |||||||
T/T | 1 | 4 | 0.50 | 0.05 | 4.85 | 0 | 0 | NA | NA | NA | |||||||