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Table 1 Proportion of immune infiltrating cells in the HGSOC (GSE135820, GSE53963, GSE32062), normal, serous, endometrioid, clear cell, and TCGA-OC databases. A difference in the proportions of immune-infiltrating cells was observed between HGSOC-135820 and the other databases. (*p < 0.05, **p < 0.01, ***p < 0.001)

From: Combined PD-1/PD-L1 and tumor-infiltrating immune cells redefined a unique molecular subtype of high-grade serous ovarian carcinoma

Type

HGSOC

Normal

Serous

Endometrioid

Clear cell

TCGA-OC

GSE135820

GSE53963

GSE32062

B cells naive

11.27%

11.15%

12.52%

12.24%

1.43%***

6.05%**

1.21%***

4.98%***

B cells memory

8.27%

12.80%

7.02%*

0.01%***

4.96%*

3.90%***

7.87%

1.31%***

Plasma cells

0.22%

0.00%

0.39%

9.17%***

10.57%***

11.21%***

8.62%***

2.63%***

T cells CD8

3.35%

3.60%

3.19%

12.98%***

7.39%**

10.00%***

9.13%

8.75%***

T cells CD4 naive

2.04%

2.01%

1.55%

0.03%***

3.93%

0.95%***

0.78%***

0.00%***

T cells CD4 memory resting

2.79%

1.75%

2.71%*

8.93%***

2.81%

9.26%**

8.62%

17.73%***

T cells CD4 memory activated

0.32%

0.01%

0.31%

0.00%*

7.19%*

3.37%***

5.91%***

1.40%***

T cells follicular helper

0.38%

1.51%

0.32%**

8.11%***

4.93%***

7.63%***

4.03%*

3.44%***

T cells regulatory (Tregs)

0.91%

2.26%

1.00%

0.00%***

0.95%***

1.21%

2.4%*

3.42%***

T cells gamma delta

1.03%

0.43%

1.11%

0.00%**

2.16%

2.66%

3.23%

0.28%***

NK cells resting

4.85%

3.69%

4.60%

1.20%***

4.31%

1.01%***

3.96%

0.34%***

NK cells activated

1.44%

1.19%

1.26%

4.65%***

4.18%*

8.50%***

3.52%*

3.72%***

Monocytes

5.63%

4.04%

6.76%

7.49%*

2.11%***

3.27%**

8.44%

2.58%***

Macrophages M0

0.55%

0.28%

0.51%

0.91%***

6.90%***

5.48%***

7.19%***

19.30%***

Macrophages M1

11.18%

13.32%

13.21%

0.98%***

6.95%***

4.08%**

5.52%*

7.85%

Macrophages M2

4.63%

3.91%

5.91%

28.03%***

4.76%

2.97%

5.30%

15.76%***

Dendritic cells resting

11.20%

13.62%

14.41%

0.02%***

6.06%

2.43%***

1.30%***

0.74%***

Dendritic cells activated

25.22%

20.00%

17.70%

0.33%***

1.58%***

4.08%***

0.39%***

2.63%***

Mast cells resting

0.01%

0.00%

0.00%

3.57%***

5.44%***

6.48%***

5.11%***

1.38%***

Mast cells activated

0.01%

0.00%

0.00%

0.44%***

8.78%***

2.25%***

4.03%***

1.16%***

Eosinophils

3.58%

3.86%

3.74%

0.36%***

0.89%***

2.14%*

2.34%

0.08%***

Neutrophils

1.13%

0.55%

1.78%

0.57%

1.73%***

1.06%

1.11%

0.52%

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BMC Genomics

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