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Table 2 Fixed amino acid substitutions predicted to affect protein function. Scores of deleterious effects of replacing D. p. pseudoobscura with the D. p. bogotana amino acids

From: Divergence of X-linked trans regulatory proteins and the misexpression of gene targets in sterile Drosophila pseudoobscura hybrids

Gene

Substitution

Polyphen-2

Provean

GA19787

S310N

0.375

−0.053

Q544L

0.001

−0.291

Ovd

M4I

0.009

−1.404

R24K

0.574

−1.763

T47S

0.991

−1.667

A72S

0.574

−0.158

A127P

0.010

0.426

L186V

0.991

−1.632

K190N

0.001

2.561

GA15499

G231R

N/A

0.224

GA14860

K528R

0.007

−0.339

GA14176

A502V

0.012

0.193

  1. Underlined are scores for amino acid substitutions predicted as damaging protein function. Bold are amino acid changes within the DNA/RNA binding domain
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BMC Genomics

ISSN: 1471-2164

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