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Table 2 Mann-Whitney U Test P Values for Fig. 2(e-h)

From: Genome-Wide association study of quantitative biomarkers identifies a novel locus for alzheimer’s disease at 12p12.1

Visit (Dosage)

CDRSB P

FAQ P

ADAS13 P

Fusiform P

bl (0 vs 1)

7.20e-21

6.65e-15

1.26e-22

4.08e-4

bl (0 vs 2)

1.85e-23

4.21e-15

6.82e-25

1.11e-2

bl (1 vs 2)

5.12e-5

2.77e-3

1.22e-4

4.31e-1

m06 (0 vs 1)

1.26e-20

9.61e-16

9.21e-20

2.47e-6

m06 (0 vs 2)

4.70e-25

1.84e-21

4.15e-25

9.68e-4

m06 (1 vs 2)

3.69e-5

3.51e-5

3.23e-5

1.51e-1

m12 (0 vs 1)

5.43e-17

2.81e-17

1.21e-12

8.42e-4

m12 (0 vs 2)

2.97e-20

4.69e-18

7.29e-25

8.60e-2

m12 (1 vs 2)

1.24e-4

9.54e-4

6.87-5

1.41e-1

m24 (0 vs 1)

1.72e-16

3.10e-18

1.05e-20

1.34e-3

m24 (0 vs 2)

9.06e-22

2.10e-19

1.98e-21

6.57e-3

m24 (1 vs 2)

8.18e-6

2.18e-4

6.54e-5

3.85e-2

  1. The index/leftmost column of the table represents the two specific allelic dosage means being compared at a specific time point. For example, in the first row, the differences in the average baseline levels for each of the four listed phenotypes (CDRSB, FAQ, ADAS13, and FreeSurfer Fusiform) are compared between individuals with 0 copies and 1 copy of the minor allele of the APOE ε4 allele. A Mann–Whitney U test p value threshold was determined using the Bonferroni correction, setting a threshold of 1.0410−3