Drug | Gene | # variants in the 32 k dataset* | Treesist-TB Mutations** |
---|---|---|---|
RIF | rpoB | 757 | N163K, V170F, L430P, Q432K, Q432L, D435Y, D435V, S441L, H445D, H445D, H445N, H445Y, H445R, H445L, S450L, L452P, I491F |
RIF | rpoC | 700 | N1239D, Q1289A |
INH | ahpC | 31 | -57C > T, −48G > A |
INH | fabG1 | 26 | -126G > A |
INH | katG | 648 | Y597D, T568P, A476V, S315T, S315N, S302R, W300C, G297V, P193fs, L159F, G156D, A144V, D142G, L141F, N138D, A109V, Y98C |
EMB | embA | 743 | -31delC, −16C > T, −16C > A |
EMB | embB | 762 | M306V, M306L, M306I, G406A, Q497K, Q497R, D1024N |
PAS | Rv2670c | 191 | A5V |
PAS | folC | 262 | Q153G, Q153A, S150G, S98G, R49Q, I43T |
PAS | thyX | 148 | -4C > T, −9G > A, −16C > T, −18G > T |
CYS | alr | 239 | Y388D, L283P, L113R, T20M |
CYS | rpoC | 700 | D485Y, I491T |
ETN | ethA | 494 | W455*, K448fs, P436fs, A352fs, P334A, F320S, L295fs, C294*, R279*, Q269*, M260I, W256*, C253F, T236fs, Y235fs, W228*, N226fs, K224*, A222V, S208L, R207G, V202F, L194P, T186P, P164R, P160fs, C137R, C137R, W116*, K103fs, W45*, K37fs, L35R, Q24*, D6fs |
ETN | fabG1 | 26 | -118C > G, −34C > T, −15C > T, −8 T > C, −8 T > A |
ETN | gyrA | 764 | A90V, S91P, D94A, D94G |
ETN | inhA | 108 | I21T, R27W, I194T, P251R |
ETN | mshA | 250 | A133fs, H175fs, V237L, A422V |