Table 1 Estimated type I error rates for the three mixed model approaches for binary traits (LEAP, GMMAT and CARAT), the LMM method (GEMMA) and logistic regression with principal component based correction (PCA)
Cohort Sample Size (N) | Sub-sample Size (0.2N) | LEAP | GMMAT | CARAT | GEMMA | PCA |
|---|---|---|---|---|---|---|
5000 | 1000 | 0.0405 | 0.04135 | 0.102. | 0.061 | 0.0575 |
10000 | 2000 | 0.0417 | 0.0475 | 0.089 | 0.046 | 0.0605 |
20000 | 4000 | 0.0450 | 0.0515 | 0.0945∗ | 0.052 | 0.0555 |