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Table 2 Putative and reported AMP sequences discovered from Rana [Lithobates] catesbeiana. Genomic and transcriptomic resources from Rana [Lithobates] catesbeiana [33] were mined using the AMP discovery pipeline based on AMPlify. Top-scoring peptide sequences were selected for synthesis and validation in vitro

From: AMPlify: attentive deep learning model for discovery of novel antimicrobial peptides effective against WHO priority pathogens

Peptide Name

Sequence

# aa

Net Chargea

MW (Da)

AMPlify Score

RaCa-1

GLLDIIKTTGKDFAVKILDNLKCKLAGGCPP

31

2

3242.93

1.0000

RaCa-2

FFPIIARLAAKVIPSLVCAVTKKC

24

4

2589.28

1.0000

Ranatuerin-2PRc*

AFLSTVKNTLTNVAGTMIDTFKCKITGVC

29

2

3077.66

1.0000

Temporin-1Cb*+

FLFPLITSFLSKFLGK

16

2

1858.30

1.0000

Palustrin-Ca*

GFLDIIKDTGKEFAVKILNNLKCKLAGGCPP

31

2

3303.97

1.0000

Ranatuerin-2RC*

GLFLDTLKGAAKDVAGKLLEGLKCKITGCKP

31

3

3188.88

1.0000

RaCa-3

GLWETIKTTGKSIALNLLDKIKCKIAGGCPP

31

3

3269.95

1.0000

Ranatuerin-2C*

GVFLDTLKGLAGKMLESLKCKIAGCKP

27

3

2821.49

0.9999

RaCa-4

FLTFPGMTFGKLLGK

15

2

1657.05

0.9997

RaCa-5

GLLDIIKDTGKTTGILMDTLKCQMTGRCPPSS

32

1

3395.02

0.9996

RaCa-6

ATAWRIPPPGMQPIIPIRIRPLCGKQ

26

4

2910.58

0.9994

RaCa-7

FFPRVLPLANKFLPTIYCALPKSVGN

26

3

2906.52

0.9985

RaCa-8

FPAIICKVSKNC

12

2

1322.65

0.9961

RaCa-9

FYFPVSRKFGGK

12

3

1432.69

0.9412

RaCa-10

ALVAKIQKFPVFNTLKLCKLELEII

25

2

2872.59

0.6063

RaCa-11

SNRDFFKVNIFRLCG

15

2

1816.11

0.6058

  1. *Previously reported amphibian peptide sequences [34, 38, 39]
  2. +Previously reported as a full-length AMP precursor sequence. Uniprot ID: C5IB07
  3. aNet charge at pH = 7
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BMC Genomics

ISSN: 1471-2164

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