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Table 1 The top 10 outlier window positions from the antler trait analysis based on corrected p-values that were within 25 kb of genes or regulatory regions up/downstream. The closest gene is listed for each window. Functions of each gene are abbreviated from RefSeq/Uniprot

From: Genomic architecture of phenotypic extremes in a wild cervid

Scaffold

Window Position

p

Gene

Function

ref0001370

16015000

2.66E-37

LGALS9

The galectins are a family of beta-galactoside-binding proteins implicated in modulating cell-cell and cell-matrix interactions.

ref0001836

5479500

1.24E-34

MTMR2

This gene is a member of the myotubularin family of phosphoinositide lipid phosphatases.

ref0000845

16534000

5.97E-33

DMBT1

Considered as a tumor suppressor gene. May play a roll in epithial differentiation.

ref0002391

7908000

1.75E-29

ITLN2

ITLN2 (Intelectin 2) is likely involved include carbohydrate binding.

ref0001924

2123500

1.52E-28

TRIM64

TRIM proteins are involved in pathogen-recognition and by regulation of transcriptional pathways in host defence (Ozato et.al., 2008).

ref0000845

16751500

1.14E-27

CD163

Involved in the clearence and endocytocis of hemoglobin/heptaglobin complexes by macrophages. May protext tissues from free hemoglobin-mediated oxidative damage.

ref0002391

7907500

1.79E-27

ITLN2

See above.

ref0000505

9079500

1.37E-26

ATP5F1A

This gene encodes a subunit of mitochondrial ATP synthase.

ref0000881

8059500

1.91E-26

MYH9

This gene encodes a conventional non-muscle myosin.

ref0002644

7312000

2.23E-26

RIMS1

The protein encoded by this gene is a RAS gene superfamily member that regulates synaptic vesicle exocytosis.