Fig. 4

H3K4me3, H2A.Z and H2B.Z overlap at promoters. A. Genome browser view (visualized using IGV) of H3K4me3, H2A.Z and H2B.Z ChIP-seq read density profiles at two genes (IMC1 and IMC4) with opposing orientations (bottom track). RNA-seq from T. gondii RH strain tachyzoites is shown in grey (from [31]). Peaks called using the peak-calling algorithm MACS2 are shown under read density profiles. B. Location of combined H3K4me3, H2A.Z and H2B.Z peaks in relation to promoter regions (defined as 1000 bp upstream of 5’UTR start, defined from RNA-seq data on tachyzoites [31]). C. Sequence motifs identified by HOMER that are significantly enriched in genomic regions where H3K4me3, H2A.Z and H2B.Z overlap